DJ Clegg, MD Wortman, SC Benoit, CC … - Diabetes, 2002 - Am Diabetes Assoc Mice respond to fatty acid synthase (FAS) inhibitors by profoundly reducing
their food intake and body weight. Evidence indicates that the central nervous
system (CNS) may be the critical site of action; however, a peripheral ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►physiology.org EK Kim, I Miller, LE Landree, FF Borisy- … - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc We previously demonstrated that C75, a specific and potent inhibitor of fatty
acid synthase (FAS), reduced food intake and decreased body weight in mice. In
the present study, we determined that these effects were not due to ... Cited by 75 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Gao, MD Lane - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Intraperitoneal (ip) injection of C75, a fatty acid synthase inhibitor, causes a
rapid (≤2-h) and persistent (to at least 24-h) ≈95% decrease in food intake.
The persistent effect seems to be due to inhibition of the fasting-induced ... Cited by 52 - Related articles - BL Direct - All 10 versions
KA Takahashi, JL Smart, H Liu, RD Cone - Endocrinology, 2004 - Endocrine Soc C75, a recently derived compound that potently suppresses feeding and induces
weight loss, has been proposed to act mainly by inhibiting fatty acid synthase
(FAS) in central neurons that control feeding. For example, normal, ... Cited by 33 - Related articles - BL Direct - All 6 versions
H Makimura, TM Mizuno, XJ Yang, J … - Diabetes, 2001 - Am Diabetes Assoc Cerulenin and a related compound, C75, have recently been reported to reduce
food intake and body weight independent of leptin through a mechanism
hypothesized, like leptin, to involve hypothalamic nutrition-sensitive ... Cited by 58 - Related articles - BL Direct - All 5 versions
- ►nih.gov T Shimokawa, MV Kumar, MD Lane - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences The fatty acid synthase inhibitor, C75, acts centrally to reduce food intake and
body weight in mice. Here we report the effects of C75 on the expression of key
orexigenic [neuropeptide Y (NPY), agouti-related protein (AgRP), and ... Cited by 116 - Related articles - BL Direct - All 9 versions
LE Landree, AL Hanlon, DW Strong, G … - Journal of Biological Chemistry, 2004 - ASBMB C75, a synthetic inhibitor of fatty acid synthase (FAS), is hypothesized to
alter the metabolism of neurons in the hypothalamus that regulate feeding
behavior to contribute to the decreased food intake and profound weight ... Cited by 65 - Related articles - BL Direct - All 5 versions
MV Kumar, T Shimokawa, TR Nagy, MD Lane - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences C75 is a potent inhibitor of fatty acid synthase that acts centrally to reduce
food intake and body weight in mice; a single dose causes a rapid (>90%)
decrease of food intake. These effects are associated with inhibition of ... Cited by 79 - Related articles - BL Direct - All 10 versions
I Miller, GV Ronnett, TH Moran, S Aja - Neuroreport, 2004 - journals.lww.com The fatty acid synthase inhibitor C75 reduces feeding rapidly and for several
days. We investigated brain sites potentially involved in actions of ipC75 in
mice by examining c-Fos. At 3 h C75 increased numbers of ... Cited by 17 - Related articles - BL Direct - All 2 versions
