- ►diabetesjournals.org W Karges, K Pechhold, S Al Dahouk, I … - Diabetes, 2002 - Am Diabetes Assoc Insulin has been used to modify T-cell autoimmunity in experimental models of
type 1 diabetes. In a large clinical trial, the effect of insulin to prevent
type 1 diabetes is currently investigated. We here show that insulin can ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org DJ Weaver Jr, B Liu, R Tisch - The Journal of Immunology, 2001 - Am Assoc Immnol We previously demonstrated that administration of plasmid DNAs (pDNAs) encoding
IL-4 and a fragment of glutamic acid decarboxylase 65 (GAD65) fused to IgGFc
induces GAD65-specific Th2 cells and prevents insulin-dependent diabetes ... Cited by 46 - Related articles - BL Direct - All 4 versions
B Balasa, BO Boehm, A Fortnagel, W Karges, … - Clinical Immunology, 2001 - Elsevier The nonobese diabetic (NOD) mouse develops spontaneous T-cell-dependent
autoimmune diabetes. We tested here whether vaccination of NOD mice with a
plasmid DNA encoding glutamic acid decarboxylase (GAD), an initial target ... Cited by 56 - Related articles - BL Direct - All 5 versions
K Pechhold, W Karges, C Blum, BO Boehm, … - Journal of Autoimmunity, 2003 - Elsevier T cell responses toward pancreatic beta cell autoantigens arise spontaneously or
on immunization in many mouse strains, yet sustained islet infiltration and
progressive diabetes rarely ensues. Most mouse diabetes models overcome the ... Cited by 19 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org A Bot, D Smith, S Bot, A Hughes, T Wolfe, L … - The Journal of Immunology, 2001 - Am Assoc Immnol The insulin B (InsB) chain bears major type 1 diabetes-associated epitopes of
significance for disease in humans and nonobese diabetic (NOD) mice. Somatic
expression of InsB chain initiated early in life by plasmid inoculation ... Cited by 75 - Related articles - BL Direct - All 3 versions
I Urbanek-Ruiz, PJ Ruiz, V Paragas, H … - Clinical Immunology, 2001 - Elsevier DNA vaccination is an effective means of protecting experimental animals against
infectious pathogens and cancer and has more recently been used to prevent
autoimmune disease. Insulin-dependent diabetes mellitus (IDDM) is an ... Cited by 53 - Related articles - BL Direct - All 5 versions
Y Glinka, R de Pooter, F Croze, GJ Prud' … - Journal of Molecular Medicine, 2003 - Springer Abstract Nonobese diabetic (NOD) mice develop a T- cell dependent autoimmune
form of diabetes, in which glutamic acid decarboxylase 65 (GAD65) is an impor-
tant islet target antigen. Intramuscular DNA vaccination with a plasmid ... Cited by 16 - Related articles - BL Direct - All 3 versions
GJ Prud'homme, Y Glinka, Y Chang, X Li - Gene Therapy of Autoimmune Diseases. Ed. Prud' …, 2005 - Springer Introduction T he ultimate goal in the treatment of autoimmune diseases is to
restore immune tolerance to the relevant target antigen(s). Short of this ideal,
the attenuation of pathogenic immune responses is a highly desirable end. ... Cited by 7 - Related articles - All 4 versions
GJ Prud'homme, Y Chang, X Li - Human gene therapy, 2002 - liebertonline.com Cytotoxic T lymphocyte antigen 4 (CTLA-4 or CD152) is a strong negative
regulator of T cell activity. Like CD28 (a positive regulator) it binds to B7-1
and B7-2, and there is no known natural selective ligand. Mono- clonal ... Cited by 47 - Related articles - BL Direct - All 4 versions
M Filippova, J Liu, A Escher - DNA and Cell Biology, 2001 - liebertonline.com Type 1 diabetes results in most cases from the destruction of insulin-secreting
beta cells by the immune system. Several immunization methods based on
administration of autoantigenic polypeptides such as insulin and glu- tamic ... Cited by 24 - Related articles - BL Direct - All 3 versions
