JP Mordes, J Leif, S Novak, C DeScipio, DL Greiner, … - Diabetes, 2002 - Am Diabetes Assoc Viral antibody–free BBDR and WF rats never develop spontaneous diabetes. BBDR rats,
however, develop autoimmune diabetes after perturbation of the immune system, eg, by viral
infection. We previously identified a disease-susceptibility locus in the BBDR rat, iddm4, ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] AM Martin, MN Maxson, J Leif, JP Mordes, DL Greiner, … - Diabetes, 1999 - Am Diabetes Assoc Diabetes-prone (DP) BB rats develop autoimmune type 1 diabetes spontaneously. At least five
loci are linked to disease expression: the major histocompati- bility complex (iddm 2), two susceptibility
loci (iddm 4 , iddm 5), and, possibly, a resistance locus (iddm 3) . Spontaneous disease ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org EP Blankenhorn, L Rodemich, C Martin-Fernandez, J … - Diabetes, 2005 - Am Diabetes Assoc BBDR rats develop autoimmune diabetes only after challenge with environmental
perturbants. These perturbants include polyinosinic:polycytidylic acid (poly I:C, a ligand of
toll-like receptor 3), agents that deplete regulatory T-cell (Treg) populations, and a non–β- ... Cited by 12 - Related articles - All 6 versions
AM Martin, EP Blankenhorn, MN Maxson, M … - DIABETES-NEW …, 1999 - Am Diabetes Assoc BB rats are used as models of autoimmune human IDDM. Genetic control of IDDM in both species
is com- plex, including both major histocompatibility complex (MHC)-linked and non–MHC-linked
genes. DP-BB rats develop IDDM spontaneously. Expression of disease in these animals ... Cited by 36 - Related articles - BL Direct - All 4 versions
L Hornum, C DeScipio, H Markholst, SA Troutman, S … - Mammalian Genome, 2004 - Springer 1 Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark 2 Department
of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane,
Philadelphia, Pennsylvania 19129, USA 3 Diabetes Division, University of Massachusetts ... Cited by 4 - Related articles - BL Direct - All 5 versions
[CITATION] Role of viruses in the pathogenesis of type 1 diabetes mellitus
VA Thomas, BA Woda, ES Handler, DL Greiner, JP … - Diabetes, 1991 - Am Diabetes Assoc Autoimmune diabetes mellitus affects greater than 50% of diabetes-prone BB (DP BB) rats but
less than 1% of diabetes-resistant BB (DR BB) rats. We report an outbreak of spontaneous diabetes
among DR BB rats that coincided with serologic evidence of the onset of viral infection. ... Cited by 46 - Related articles - All 4 versions
- ►jimmunol.org D Zipris, JL Hillebrands, RM Welsh, J Rozing … - The Journal of …, 2003 - Am Assoc Immnol Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in
humans. This pathogenic process can be modeled in the BBDR rat, which develops pancreatic
insulitis and type 1A-like diabetes after infection with Kilham's rat virus (RV). The ... Cited by 32 - Related articles - BL Direct - All 6 versions
L Hornum, J Rømer, H Markholst - Diabetes, 2002 - Am Diabetes Assoc Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling
human type 1 diabetes. They also exhibit lifelong T-cell lymphopenia. Functional and genetic
data support the hypothesis that the gene responsible for the lymphopenia, Lyp, is also a ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►nih.gov M Pandarpurkar, L Wilson-Fritch, S … - Proceedings of the …, 2003 - National Acad Sciences Apoptosis is a regulated cell death program controlled by extrinsic and intrinsic signaling
pathways. The intrinsic pathway involves stress signals that activate pro-apoptotic members
of the Bcl-2 family, inducing permeabilization of mitochondria and release of apoptogenic ... Cited by 48 - Related articles - BL Direct - All 11 versions
