F Krempler, H Esterbauer, R Weitgasser, C … - Diabetes, 2002 - Am Diabetes Assoc Obesity is frequently associated with type 2 diabetes. We previously observed an
association of a functional G/A polymorphism in the uncoupling protein 2 (UCP2)
promoter with obesity. The wild-type G allele was associated with reduced ... Cited by 94 - Related articles - BL Direct - All 4 versions
G Sesti, M Cardellini, MA Marini, S Frontoni, … - Diabetes, 2003 - Am Diabetes Assoc It was reported that the common −866G/A polymorphism in the promoter of the
human uncoupling protein-2 (UCP2) gene, which enhances its trascriptional
activity, is associated with increased mRNA levels in human adipocytes and ... Cited by 86 - Related articles - BL Direct - All 4 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA Kern, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance,
and impaired -cell function. Uncoupling protein-2 (UCP2) is a widely expressed
inner mitochondrial membrane protein. Common polymorphisms of the UCP2 gene ... Cited by 62 - Related articles - BL Direct - All 5 versions
MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane
carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP
synthesis. The −866G/A polymorphism in the UCP2 gene, which enhances its ... Cited by 62 - Related articles - BL Direct - All 5 versions
M Sasahara, M Nishi, H Kawashima, K Ueda, … - Diabetes, 2004 - Am Diabetes Assoc Common uncoupling protein 2 (UCP2) promoter polymorphism −866G/A is reported
to be associated with its expression in adipose tissue and the risk of obesity
in Caucasians. On the other hand, several studies suggested that UCP2 ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Bulotta, O Ludovico, A Coco, R Di Paola, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Uncoupling protein-2 (UCP2) regulates insulin secretion and may play an
important role in linking obesity to type 2 diabetes (T2D). Previous studies of
the role of the UCP2 promoter –866G/A single nucleotide polymorphisms ... Cited by 33 - Related articles - All 5 versions
- ►diabetesjournals.org S Le Fur, C Le Stunff, C Dos Santos, P … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP) 2 is a member of the mitochondrial transporter
superfamily that uncouples proton entry in the mitochondrial matrix from ATP
synthesis. Although its physiological role remains to be established, UCP2 ... Cited by 38 - Related articles - BL Direct - All 5 versions
LT Dalgaard, G Andersen, LH Larsen, TIA … - Obesity, 2003 - nature.com Research Methods and Procedures: The human UCP2 promoter was characterized by
reporter gene analysis in cell lines derived from skeletal muscle, white adipose
tissue, and embryonic tissue. We analyzed the core promoter for ... Cited by 22 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org SS Dhamrait, JW Stephens, JA Cooper, J … - European heart journal, 2004 - Eur Soc Cardiology Methods and results Amongst 465 diabetic men (age 61.7±13.3 years), an
association of the UCP2-866A allele with significantly lower TAOS in those
without CHD was even more pronounced in those with CHD (TAOS 30.1±16.1% ... Cited by 52 - Related articles - All 4 versions
