A Kretowski, K Mironczuk, A Karpinska, U … - Diabetes, 2002 - Am Diabetes Assoc Type 1 diabetes is believed to be a Th1 lymphocyte–mediated disease, and both
environmental and genetic factors play a role in its pathogenesis. It was
recently found that interleukin (IL)-18 acts as a proinflammatory cytokine ... Cited by 100 - Related articles - BL Direct - All 5 versions
V Giedraitis, B He, WX Huang, J Hillert - Journal of Neuroimmunology, 2001 - Elsevier Interleukin-18 is a proinflammatory cytokine, which strongly induces IFN-γ
production. We have cloned the human IL-18 promoter and screened for possible
polymorphisms. Three single nucleotide polymorphisms were detected in the ... Cited by 165 - Related articles - All 7 versions
A Ide, E Kawasaki, N Abiru, F Sun, M … - Journal of Autoimmunity, 2004 - Elsevier Interleukin-18 (IL-18) is a potent proinflammatory cytokine which is strongly
associated with the development of diabetes in NOD mice. To test the putative
involvement of IL-18 gene polymorphism in predisposition to human type 1 ... Cited by 54 - Related articles - All 4 versions
SP Sivalingam, KH Yoon, DR Koh, KY Fong - Tissue Antigens, 2003 - interscience.wiley.com Abstract: Rheumatoid arthritis (RA) is a chronic arthritic condition that can
lead to deformities and disabilities. Although numerous studies reported the
association of human leukocyte antigen (HLA)-DRB1*04 and RA, other genes, ... Cited by 46 - Related articles - BL Direct - All 4 versions
TTESK Morohashi, F Gejyo, T Takada - Tissue Antigens - interscience.wiley.com Abstract: Interleukin-18 (IL-18) and interleukin-12 (IL-12) synergistically
stimulate interferon-γ (IFN-γ) production from Th1 cells. The levels of serum
IL-18 and IFN-γ and bronchoalveolar lavage fluid IL-18 were elevated in ... Cited by 52 - Related articles - BL Direct - All 5 versions
F Nicoletti, I Conget, R Di Marco, AM … - Diabetologia, 2001 - Springer IL-18 is another type 1 cytokine primarily pro- duced by macrophages and closely
related to the IL- 1 family of cytokines [1]. It has been shown to play a
pivotal part in the generation of type 1 cytokine re- sponses through its ... Cited by 65 - Related articles - BL Direct - All 4 versions
S Kruse, J Kuehr, M Moseler, MV Kopp, T … - The Journal of Allergy and Clinical Immunology, 2003 - Elsevier Background: Atopy has been linked to chromosome 11q22, a region that harbors the
IL18 gene. IL-18 enhances IL-4/IL-13 production and induces IgE production that
is directly associated with the pathogenesis of atopic disorders. ... Cited by 76 - Related articles - BL Direct - All 8 versions
T Sugiura, Y Kawaguchi, M Harigai, H … - Genes and immunity, 2002 - ncbi.nlm.nih.gov Recently, we reported that serum concentration of IL-18 is strikingly high in
patients with adult-onset Still's disease (AOSD). The aim of the present study
was to screen for genetic polymorphisms in the human IL-18 (hIL-18) gene ... Cited by 60 - Related articles - BL Direct
JS Szeszko, JMM Howson, JD Cooper, NM … - Diabetes, 2006 - Am Diabetes Assoc Recently, the interleukin-18 cytokine gene (IL18) was reported to be associated
with type 1 diabetes. In the present report, we calculated that the reported
genotypes of the two 5′ region/promoter single nucleotide polymorphisms ... Cited by 19 - Related articles - BL Direct - All 6 versions
S Frigerio, GA Holländer, U Zumsteg - Hormone research, 2000 - content.karger.com Background: Preclinical stages of type 1 diabetes are characterized by
infiltrating T cells and by the peri- and intra-islet accumulation of
pro-inflammatory mediators, such as IFN . Methods/Results: Using ... Cited by 30 - Related articles - BL Direct - All 5 versions
