H Okazaki, J Osuga, Y Tamura, N Yahagi, S Tomita, F … - Diabetes, 2002 - Am Diabetes Assoc Hormone-sensitive lipase (HSL) is presumed to be essential for lipolysis, which is defined as
the mobilization of free fatty acids from adipocytes. In the present study, we investigated the effects
of various lipolytic hormones on the lipolysis in adipocytes derived from mouse embryonic ... Cited by 92 - Related articles - BL Direct - All 7 versions
SP Wang, N Laurin, J Himms-Hagen, MA Rudnicki, E … - Obesity, 2001 - nature.com Results: Homozygous HSL -/- mice have no detectable HSL peptide or cholesteryl esterase activity
in adipose tissue, and heterozygous mice have intermediate levels with respect to wild-type and
deficient littermates. HSL-deficient mice have normal body weight but reduced abdominal ... Cited by 125 - Related articles - BL Direct - All 3 versions
G Haemmerle, R Zimmermann, M Hayn, C Theussl, … - Journal of Biological …, 2002 - ASBMB Hormone-sensitive lipase (HSL) is expressed predominantly in white and brown adipose tissue
where it is believed to play a crucial role in the lipolysis of stored triglycerides (TG), thereby providing
the body with energy substrate in the form of free fatty acids (FFA). From in vitro assays, ... Cited by 189 - Related articles - BL Direct - All 5 versions
J Osuga, S Ishibashi, T Oka, H Yagyu, R … - Proceedings of the …, 2000 - National Acad Sciences Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol
stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and
macrophages. To elucidate its precise role in the development of obesity and ... Cited by 272 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org R Roduit, P Masiello, SP Wang, H Li, GA Mitchell, M … - Diabetes, 2001 - Am Diabetes Assoc Endogenous lipid stores are thought to be involved in the mechanism whereby the β-cell adapts
its secretory capacity in obesity and diabetes. In addition, hormone-sensitive lipase (HSL) is
expressed in β-cells and may provide fatty acids necessary for the generation of coupling ... Cited by 74 - Related articles - BL Direct - All 5 versions
H Mulder, M Sörhede-Winzell, JA Contreras, M Fex, … - Journal of Biological …, 2003 - ASBMB Lipid metabolism plays an important role in glucose homeostasis under normal and pathological
conditions. In adipocytes, skeletal muscle, and pancreatic β-cells, lipids are mobilized from acylglycerides
by the hormone-sensitive lipase (HSL). Here, the consequences of a targeted disruption ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►jlr.org FB Kraemer, WJ Shen - The Journal of Lipid Research, 2002 - ASBMB Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing
triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid
and water soluble substrates. HSL activity is regulated post-translationally by ... Cited by 116 - Related articles - BL Direct - All 5 versions
GM Clifford, C Londos, FB Kraemer, RG Vernon, SJ … - Journal of Biological …, 2000 - ASBMB Adipocyte lipolysis was compared with hormone-sensitive lipase (HSL)/perilipin subcellular distribution
and perilipin phosphorylation using Western blot analysis. Under basal conditions, HSL resided
predominantly in the cytosol and unphosphorylated perilipin upon the lipid droplet. Upon ... Cited by 156 - Related articles - BL Direct - All 4 versions
- ►jbc.org G Haemmerle, R Zimmermann, JG Strauss, D … - Journal of Biological …, 2002 - ASBMB Hormone-sensitive lipase (HSL) is believed to play an important role in the mobilization of fatty
acids from triglycerides (TG), diglycerides, and cholesteryl esters in various tissues. Because
HSL-mediated lipolysis of TG in adipose tissue (AT) directly feeds non-esterified fatty ... Cited by 79 - Related articles - BL Direct - All 8 versions
KG Soni, R Lehner, P Metalnikov, P O'Donnell, M … - Journal of Biological …, 2004 - ASBMB Hydrolysis of triglycerides is central to energy homeostasis in white adipose tissue (WAT).
Hormone-sensitive lipase (HSL) was previously felt to mediate all lipolysis in WAT.
Surprisingly, HSL-deficient mice show active HSL-independent lipolysis, suggesting that ... Cited by 71 - Related articles - BL Direct - All 5 versions
