- ►diabetesjournals.org JJ Senn, PJ Klover, IA Nowak, RA Mooney - Diabetes, 2002 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines that have been
associated with insulin resistance and type 2 diabetes. A two- to threefold
elevation of circulating IL-6 has been observed in these conditions. ... Cited by 314 - Related articles - BL Direct - All 6 versions
JJ Senn, PJ Klover, IA Nowak, TA Zimmers, … - Journal of Biological Chemistry, 2003 - ASBMB Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in
insulin resistance during infection, cachexia, and obesity. We recently
demonstrated that IL-6 inhibits insulin signaling in hepatocytes (Senn, JJ, ... Cited by 273 - Related articles - BL Direct - All 9 versions
PJ Klover, TA Zimmers, LG Koniaris, RA … - Diabetes, 2003 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines associated with
the insulin resistance of obesity and type 2 diabetes. There is, however, little
direct evidence in vivo for a causative role of IL-6 in insulin resistance. ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►jbc.org V Rotter, I Nagaev, U Smith - Journal of Biological Chemistry, 2003 - ASBMB Several studies have shown a relationship between interleukin (IL) 6 levels and
insulin resistance. We here show that human subcutaneous adipose cells, like
3T3-L1 cells, are target cells for IL-6. To examine putative mechanisms and ... Cited by 273 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is
elevated in various insulin-resistant states including type 2 diabetes, obesity,
cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in ... Cited by 163 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JP Bastard, M Maachi, JT Van Nhieu, C Jardel … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc OBESITY AND TYPE 2 diabetes are associated with impaired insulin action on
peripheral target tissues (ie adipose tissue and skeletal muscle) (1, 2). The
mechanisms that could explain such a link are not clearly elucidated, ... Cited by 231 - Related articles - BL Direct - All 4 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in
part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic
insulin resistance in vitro and in vivo. The importance of endogenous IL-6, ... Cited by 89 - Related articles - BL Direct - All 5 versions
B Vozarova, C Weyer, K Hanson, PA Tataranni … - Obesity, 2001 - nature.com Objective: Plasma concentrations of interleukin-6 (IL-6), a proinflammatory
cytokine produced and released in part by adipose tissue, are elevated in people
with obesity and type 2 diabetes. Because recent studies suggest that ... Cited by 272 - Related articles - BL Direct - All 4 versions
- ►endojournals.org C Tsigos, DA Papanicolaou, I Kyrou, R … - Journal of Clinical Endocrinology & Metabolism, 1997 - Endocrine Soc Inflammatory cytokines have metabolic actions that probably contribute to the
general adaptation of the organism during infectious or inflammatory stress. To
examine the effects of interleukin 6 (IL-6), the main circulating cytokine, ... Cited by 185 - Related articles - BL Direct - All 4 versions
