GM Beattie, AMP Montgomery, AD Lopez, E … - Diabetes, 2002 - Am Diabetes Assoc Human islet expansion in monolayer culture leads to loss of function and
senescence. By maintaining the 3-D configuration of islets in fibrin gels, it is
feasible to expand β-cells in response to hepatocyte growth factor (HGF) ... Cited by 83 - Related articles - BL Direct - All 5 versions
- ►endojournals.org GM Beattie, V Cirulli, AD Lopez, A Hayek - Journal of Clinical Endocrinology & Metabolism, 1997 - Endocrine Soc Cell transplantation as a therapy for type 1 diabetes is facilitated by ex vivo
cell expansion of pancreatic ß-cells without loss of differentiative
characteristics. The aim of this study was to determine the optimal ... Cited by 78 - Related articles - BL Direct - All 4 versions
GM Beattie, JS Rubin, MI Mally, T Otonkoski, … - Diabetes, 1996 - Am Diabetes Assoc Ex vivo expansion of human fetal pancreatic endocrine cells is important for
biological studies and as a potential tissue source for transplantation in
insulin-deficient states. In tissue culture experiments involving the use ... Cited by 119 - Related articles - BL Direct - All 7 versions
MC Gershengorn, AA Hardikar, C Wei, E … - Science, 2004 - sciencemag.org Insulin-expressing beta cells, found in pancreatic islets, are capable of
generating more beta cells even in the adult. We show that fibroblast-like cells
derived from adult human islets donated postmortem proliferate readily in ... Cited by 184 - Related articles - All 11 versions
- ►shouxi.net N Weinberg, L Ouziel-Yahalom, S Knoller, S … - Diabetes, 2007 - Am Diabetes Assoc Understanding and manipulating pancreatic β-cell proliferation is a major
challenge for pancreas biology and diabetes therapy. Recent studies have raised
the possibility that human β-cells can undergo dedifferentiation and give ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] TL Halvorsen, GM Beattie, AD Lopez, A Hayek … - Journal of Endocrinology, 2000 - Soc Endocrinology Widespread application of -cell replacement strategies for diabetes is dependent
upon the availability of an unlimited supply of cells exhibiting appropriate
glucose-responsive insulin secretion. Therefore, a great deal of effort has ... Cited by 76 - Related articles - BL Direct - All 5 versions
F Ris, E Hammar, D Bosco, C Pilloud, K … - Diabetologia, 2002 - Springer Aims/hypothesis. Human islet cells survive poorly in culture and are overgrown
by non-endocrine cells. The aims of this study were to sort human beta cells and
to develop approaches for their improved survival in culture. Methods. ... Cited by 38 - Related articles - BL Direct - All 4 versions
C Öberg-Welsh - Pancreas, 2001 - journals.lww.com To study the influence of extracellular matrix (ECM) on isolated fetal porcine
islet-like cell clusters (ICC), ICC were cultured either embedded in Matrigel
(MG) or growth factor-reduced Matrigel (MG-GF), or in the absence of matrix ... Cited by 15 - Related articles - BL Direct - All 6 versions
DW Fraga, O Sabek, DK Hathaway, AO Gaber - Transplantation, 1998 - journals.lww.com Background. The preservation of sufficient quantities of islets for human
transplantation has proven to be a tenacious problem for researchers and
transplant programs. Beyond the variables associated with islet ... Cited by 35 - Related articles - BL Direct - All 3 versions
L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - Biochemical and Biophysical Research …, 2006 - Elsevier Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet
insulin-producing β cells. Insulin administration does not prevent long-term
complications of the disease, since the optimal insulin dosage is difficult ... Cited by 52 - Related articles - All 4 versions
