- ►diabetesjournals.org M Nakazaki, A Crane, M Hu, V Seghers, S … - Diabetes, 2002 - Am Diabetes Assoc Whereas the loss of ATP-sensitive K + channel (K ATP channel) activity in human
pancreatic β-cells causes severe hypoglycemia in certain forms of
hyperinsulinemic hypoglycemia, similar channel loss in sulfonylurea ... Cited by 53 - Related articles - BL Direct - All 5 versions
C Shiota, O Larsson, KD Shelton, M Shiota, … - Journal of Biological Chemistry, 2002 - ASBMB The ATP-sensitive potassium channel is a key molecular complex for
glucose-stimulated insulin secretion in pancreatic cells. In humans, mutations
in either of the two subunits for this channel, the sulfonylurea type 1 ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►rupress.org L Eliasson, X Ma, E Renstrom, S Barg, PO … - Journal of General Physiology, 2003 - jgp.rupress.org Measurements of membrane capacitance were applied to dissect the cellular
mechanisms underlying PKA-dependent and -independent stimulation of insulin
secretion by cyclic AMP. Whereas the PKA-independent ... Cited by 113 - Related articles - BL Direct - All 5 versions
M Düfer, D Haspel, P Krippeit-Drews, L … - Diabetologia, 2004 - Springer Aims/hypothesis. SUR1(ABCC8) −/− mice lacking func- tional KATP channels are
an appropriate model to test the significance of KATP channels in beta-cell
function. We examined how this gene deletion interferes with ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►jbc.org M Nenquin, A Szollosi, L Aguilar-Bryan, J … - Journal of Biological Chemistry, 2004 - ASBMB In normal -cells glucose induces insulin secretion by activating both a
triggering pathway (closure of K ATP channels, depolarization, and rise in
cytosolic [Ca 2+ ] i ) and an amplifying pathway (augmentation of Ca 2+ ... Cited by 44 - Related articles - BL Direct - All 5 versions
D Haspel, P Krippeit-Drews, L Aguilar-Bryan, … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 913–921 DOI 10.1007/s00125-005-1720-8 ARTICLE D.
Haspel . P. Krippeit-Drews . L. Aguilar-Bryan . J. Bryan . G. Drews . ... Cited by 11 - Related articles - All 3 versions
- ►nih.gov G Kang, OG Chepurny, GG Holz - The Journal of Physiology, 2001 - Physiological Soc CICR was triggered by the GLP-1 receptor agonist exendin-4, an effect mimicked
by caffeine, Sp-cAMPS or forskolin. CICR required influx of Ca 2+ through L-type
voltage-dependent Ca 2+ channels, and was blocked by treatment with ... Cited by 94 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org T Shibasaki, Y Sunaga, S Seino - Diabetes, 2004 - Am Diabetes Assoc Intracellular ATP, cAMP, and Ca 2+ are major signals involved in the regulation
of insulin secretion in the pancreatic ß-cell. We recently found that the
ATP-sensitive K + channel (K ATP channel) as an ATP sensor, cAMP-GEFII as a ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►physiology.org NM Doliba, W Qin, MZ Vatamaniuk, C Li, D … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Inhibition of ATP-sensitive K + (K ATP ) channels by an increase in the ATP/ADP
ratio and the resultant membrane depolarization are considered essential in the
process leading to insulin release (IR) from pancreatic -cells stimulated ... Cited by 37 - Related articles - BL Direct - All 6 versions
X Geng, L Li, S Watkins, PD Robbins, P Drain - Diabetes, 2003 - Am Diabetes Assoc With ATP sites on K ir 6.2 that inhibit activity and ADP sites on SUR1 that
antagonize the inhibition, ATP-sensitive potassium channels (K ATP channels) are
designed as exquisite sensors of adenine nucleotide levels that signal ... Cited by 63 - Related articles - BL Direct - All 4 versions
