J Zhang, C Gerhardinger, M Lorenzi - Diabetes, 2002 - Am Diabetes Assoc Diabetic retinal microangiopathy is characterized by increased permeability, leukostasis,
microthrombosis, and apoptosis of capillary cells, all of which could be caused or compounded
by activation of complement. In this study, we observed deposition of C5b-9, the terminal ... Cited by 48 - Related articles - BL Direct - All 4 versions
GB Rosoklija, AJ Dwork, DS Younger, G Karlikaya, N … - Acta neuropathologica, 2000 - Springer Abstract Quantitative immunocytochemical analysis of complement proteins (CP) was performed
on sural nerve biopsies from 15 patients with diabetic neuropathy (DN) and 18 nondiabetic patients
with other forms of chronic neuropathy (ON). The mean age of the patients and the ... Cited by 20 - Related articles - BL Direct - All 3 versions
X Qin, A Goldfine, N Krumrei, L Grubissich, J Acosta, M … - Diabetes, 2004 - Am Diabetes Assoc Micro- and macrovascular diseases are major causes of morbidity and mortality in the diabetic
population, but the cellular and molecular mechanisms that link hyperglycemia to these complications
remain incompletely understood. We proposed that in human diabetes, inhibition by ... Cited by 38 - Related articles - BL Direct - All 4 versions
A Accardo-Palumbo, G Triolo, G Colonna-Romano, M … - Diabetologia, 2000 - Springer Several lines of evidence suggest that one of the pri- mary events in the course of diabetic vascular
pathol- ogy is an alteration affecting the endothelial cell func- tion, including abnormalities of
vessel tone and per- meability, coagulation, blood flow, basement mem- brane synthesis ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►iovs.org VB Gerl, J Bohl, S Pitz, B Stoffelns, N Pfeiffer, S … - … ophthalmology & visual …, 2002 - ARVO METHODS. Eyes of 50 deceased donors with diabetic retinopathy and of 10 nondiabetic subjects
with uveal melanoma (n = 6) or phthisical eyes (n = 4), as well as eyes of 16 deceased donors
without diabetic retinopathy were subjected to immunohistochemical studies, using a ... Cited by 21 - Related articles - BL Direct - All 3 versions
W Sun, C Gerhardinger, Z Dagher, T Hoehn, M Lorenzi - Diabetes, 2005 - Am Diabetes Assoc The prevention of diabetic retinopathy requires drugs that leverage the benefits of glycemic control
without adding the burden of side effects. Aspirin at dosages of 1–1.5 g/day has prevented manifestations
of diabetic retinal microangiopathy in a clinical trial as well as in studies with dogs. ... Cited by 24 - Related articles - BL Direct - All 6 versions
CS Davies, CL Harris, BP Morgan - Immunology, 2005 - pubmedcentral.nih.gov Type 1 diabetes is associated with anaemia. Although the underlying mechanisms remain
unclear, the accompanying reticulocytosis implies that erythrocyte lifespan in the circulation is
shortened. Among the factors that permit prolonged survival of erythrocytes are the ... Cited by 15 - Related articles - All 7 versions
- ►pnas.org J Acosta, J Hettinga, R Flückiger, N … - Proceedings of the …, 2000 - National Acad Sciences Activated terminal complement proteins C5b to C9 form the membrane attack complex
(MAC) pore. Insertion of the MAC into endothelial cell membranes causes the release of growth
factors that stimulate tissue growth and proliferation. The complement regulatory ... Cited by 80 - Related articles - BL Direct - All 9 versions
N Uesugi, N Sakata, M Nangaku, M Abe, S Horiuchi … - American Journal of …, 2004 - Elsevier Although recent studies have emphasized the pathogenic role of intrarenal muscular arteries
in patients with diabetic nephropathy, notice has not been taken of their pathological
characteristics. We focused on medial smooth muscle cell (SMC) injury and the ... Cited by 13 - Related articles - BL Direct - All 12 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when intracellular
glucose concentrations are high, and it can generate cellular stress through several
mechanisms. The role of the polyol pathway in the pathogenesis of diabetic retinopathy ... Cited by 65 - Related articles - BL Direct - All 4 versions
