M Ridderstråle, E Carlsson, M Klannemark, A … - Diabetes, 2002 - Am Diabetes Assoc The human transcription factor FOXC2 has recently been shown to protect against
diet-induced insulin resistance in transgenic mice. We investigated the
expression of FOXC2 in fat and muscle and performed a genetic analysis in ... Cited by 36 - Related articles - BL Direct - All 6 versions
P Kovacs, A Lehn-Stefan, M Stumvoll, C … - Diabetes, 2003 - Am Diabetes Assoc FOXC2 is a winged helix gene that has been shown to counteract obesity,
hypertriglyceridemia, and diet-induced insulin resistance in rodents. Therefore,
FOXC2 was analyzed as a candidate gene for susceptibility to type 2 ... Cited by 21 - Related articles - BL Direct - All 5 versions
H Osawa, H Onuma, A Murakami, M Ochi, T … - Diabetes, 2003 - Am Diabetes Assoc FOXC2, a forkhead/winged helix transcription factor, represents a promising
candidate gene for type 2 diabetes since transgenic mice that specifically
overexpress this gene in adipocytes are lean and insulin sensitive. To ... Cited by 17 - Related articles - BL Direct - All 5 versions
K Yanagisawa, L Hingstrup Larsen, G … - Diabetologia, 2003 - Springer Aims/hypothesis. The transcription factor FOXC2 plays a key role in adipocyte
differentiation and the FOXC2 gene is a candidate gene for Type 2 diabetes,
obesity and dyslipidaemia. We investigated whether the FOXC2 -512C>T ... Cited by 18 - Related articles - BL Direct - All 3 versions
A Cederberg, LM Grønning, B Ahrén, K … - Cell, 2001 - Elsevier Obesity, hyperlipidemia, and insulin resistance are common forerunners of type 2
diabetes mellitus. We have identified the human winged helix/forkhead
transcription factor gene FOXC2 as a key regulator of adipocyte metabolism. ... Cited by 208 - Related articles - BL Direct - All 11 versions
- ►endojournals.org LM Gronning, A Cederberg, N Miura, S … - Molecular Endocrinology, 2002 - Endocrine Soc WE HAVE RECENTLY shown that Foxc2 is expressed in adipose tissue during
postnatal life, and that mice overexpressing Foxc2 in white (WAT) and brown
adipose tissue have reduced WAT with a brown fat-like histology expressing ... Cited by 40 - Related articles - BL Direct - All 4 versions
X Yang, S Enerbäck, U Smith - Obesity, 2003 - nature.com Results: The expression of FOXC2, MASK, MAP3K5, retinoblastoma protein (pRb),
peroxisome proliferator-activated protein gamma (PPAR ), and retinoid X receptor
gamma (RXR ) was decreased in the insulin-resistant compared with insulin- ... Cited by 53 - Related articles - BL Direct - All 3 versions
A Fritsche, F Machicao, H Staiger, HU Häring … - Diabetologia, 2004 - Springer To the Editor: A recent paper reported an association between the −512C>T
promoter polymorphism in the forkhead box C2 (FOXC2) gene and increased serum
C-peptide and hyper- triglyceridaemia in normal-glucose-tolerant subjects ... Cited by 3 - Related articles - BL Direct - All 4 versions
E Carlsson, L Groop, M Ridderstråle - International Journal of Obesity, 2004 - nature.com FOXC2 –512C>T allele and genotype distribution did not differ between patients
with type 2 diabetes and control subjects, but the C/C genotype was associated
with increased body mass index (BMI, kg/m 2 ) (P a =0.03) among type 2 ... Cited by 12 - Related articles - All 3 versions
C Christiansen, P Poulsen, H Beck-Nielsen - Diabetic Medicine, 1999 - ingentaconnect.com Aims The physiological role of the adrenergic b-3 receptor is poorly understood
in man but the Trp64Arg mutation of the receptor gene has been related to the
insulin resistance syndrome, an earlier onset of diabetes and rapid weight ... Cited by 12 - Related articles - BL Direct - All 4 versions
