S Obici, Z Feng, K Morgan, D Stein, G Karkanias, L … - Diabetes, 2002 - Am Diabetes Assoc The hypothalamus and other regions within the central nervous system (CNS) link the sensing
of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular
(ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose ... Cited by 219 - Related articles - BL Direct - All 5 versions
S Obici, Z Feng, A Arduini, R Conti, L Rossetti - Nature medicine, 2003 - nature.com The enzyme carnitine palmitoyltransferase-1 (CPT1) regulates long-chain fatty acid (LCFA) entry
into mitochondria, where the LCFAs undergo -oxidation. To investigate the mechanism(s) by
which central metabolism of lipids can modulate energy balance, we selectively reduced ... Cited by 200 - Related articles - BL Direct - All 6 versions
S Obici, Z Feng, K Morgan, D Stein, G Karkanias, L … - DIABETES, 2002 - Am Diabetes Assoc The hypothalamus and other regions within the central nervous system (CNS) link the sensing
of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular
(ICV) adminis- tration of the long-chain fatty acid oleic acid markedly inhibits glucose ... Related articles - All 2 versions
- ►yu.edu [PDF] TKT Lam, A Pocai, R Gutierrez-Juarez, S Obici, J … - Nature medicine, 2005 - medscape.com Increased glucose production is a hallmark of type 2 diabetes and alterations in lipid metabolism
have a causative role in its pathophysiology. Here we postulate that physiological increments
in plasma fatty acids can be sensed within the hypothalamus and that this sensing is ... Cited by 118 - Related articles - All 9 versions
K Morgan, S Obici, L Rossetti - Journal of Biological Chemistry, 2004 - ASBMB Central administration of the long-chain fatty acid oleic acid inhibits food intake and glucose
production in rats. Here we examined whether short term changes in nutrient availability can
modulate these metabolic and behavioral effects of oleic acid. Rats were divided in three ... Cited by 55 - Related articles - BL Direct - All 4 versions
TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend, … - Science, 2000 - sciencemag.org With the escalation of obesity-related disease, there is great interest in defining the mechanisms
that control appetite and body weight. We have identified a link between anabolic energy metabolism
and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty ... Cited by 461 - Related articles - BL Direct - All 7 versions
W He, TKT Lam, S Obici, L Rossetti - Nature neuroscience, 2006 - nature.com The sensing of circulating nutrients within the mediobasal hypothalamus may be critical for energy
homeostasis. To induce a sustained impairment in hypothalamic nutrient sensing, adeno-associated
viruses (AAV) expressing malonyl–coenzyme A decarboxylase (MCD; an enzyme ... Cited by 78 - Related articles - BL Direct - All 6 versions
TKT Lam, GJ Schwartz, L Rossetti… - Nature neuroscience, 2005 - dept.wofford.edu Energy homeostasis is maintained by multiple mechanisms that gather information on the body's
nutritional status and make appro- priate behavioral and metabolic responses to changes in
fuel avail- ability. Although it is clear that nutrient-stimulated, gut-derived signals are ... Cited by 120 - Related articles - All 5 versions
S Obici, BB Zhang, G Karkanias, L Rossetti - Nature medicine, 2002 - nature.com Circulating insulin inhibits endogenous glucose production. Here we report that bidirectional
changes in hypothalamic insulin signaling affect glucose production. The infusion of either insulin
or a small-molecule insulin mimetic in the third cerebral ventricle suppressed glucose ... Cited by 225 - Related articles - BL Direct - All 4 versions
S Obici, Z Feng, G Karkanias, DG Baskin, L Rossetti - Nature neuroscience, 2002 - nature.com We investigated the role of hypothalamic insulin signaling in the regulation of energy balance
and insulin action in rats through selective decreases in insulin receptor expression in discrete
hypothalamic nuclei. We generated an antisense oligodeoxynucleotide directed against ... Cited by 228 - Related articles - BL Direct - All 4 versions
