- ►diabetesjournals.org B Huang, P Wu, MM Bowker-Kinley, RA Harris - Diabetes, 2002 - Am Diabetes Assoc Pyruvate dehydrogenase kinase (PDK) catalyzes phosphorylation and inactivation
of the pyruvate dehydrogenase complex (PDC). Two isoforms of this mitochondrial
kinase (PDK2 and PDK4) are induced in a tissue-specific manner in response ... Cited by 84 - Related articles - BL Direct - All 5 versions
HS Kwon, B Huang, TG Unterman, RA Harris - Diabetes, 2004 - Am Diabetes Assoc Starvation and diabetes increase pyruvate dehydrogenase kinase-4 (PDK4)
expression, which conserves gluconeogenic substrates by inactivating the
pyruvate dehydrogenase complex. Mechanisms that regulate PDK4 gene ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] MJ Holness, ND Smith, K Bulmer, T Hopkins … - Biochemical Journal, 2002 - pubmedcentral.nih.gov Inactivation of cardiac pyruvate dehydrogenase complex (PDC) after prolonged
starvation and in response to hyperthyroidism is associated with enhanced
protein expression of pyruvate de- hydrogenase kinase (PDK) isoform 4. The ... Cited by 32 - Related articles - BL Direct - All 7 versions
P Wu, PV Blair, J Sato, J Jaskiewicz, KM … - Archives of Biochemistry and Biophysics, 2000 - Elsevier Covalent modification of the pyruvate dehydrogenase complex provides an
important regulatory mechanism for controlling the disposal of glucose and other
compounds metabolized to pyruvate. Regulation of the complex by this ... Cited by 77 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] MM Bowker-Kinley, WI Davis, P Wu, RA … - Biochemical Journal, 1998 - pubmedcentral.nih.gov Tissue distribution and kinetic parameters for the four iso- enzymes of pyruvate
dehydrogenase kinase (PDK1, PDK2, PDK3 and PDK4) identified thus far in mammals
were analysed. It appeared that expression of these isoenzymes occurs in a ... Cited by 184 - Related articles - BL Direct - All 8 versions
- ►nih.gov [PDF] MJ Holness, K Bulmer, ND Smith, MC Sugden - Biochemical Journal, 2003 - pubmedcentral.nih.gov Biochem. J. (2003) 369, 687–695 (Printed in Great Britain) ... Investigation
of potential mechanisms regulating protein expression of ... Mark J. HOLNESS,
Karen BULMER, Nicholas D. SMITH and Mary C. SUGDEN Cited by 31 - Related articles - BL Direct - All 8 versions
MC Sugden, K Bulmer, D Augustine, MJ … - Diabetes, 2001 - Am Diabetes Assoc The pyruvate dehydrogenase complex (PDC) has a pivotal role in islet metabolism.
The pyruvate dehydrogenase kinases (PDK1–4) regulate glucose oxidation through
inhibitory phosphorylation of PDC. Starvation increases islet PDK activity ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►arizona.edu [PDF] MC Sugden, K Bulmer, GF Gibbons, MJ … - Archives of Biochemistry and Biophysics, 2001 - Elsevier The pyruvate dehydrogenase complex (PDC) occupies a strategic role in renal
intermediary metabolism, via partitioning of pyruvate flux between oxidation and
entry into the gluconeogenic pathway. Inactivation of PDC via activation of ... Cited by 31 - Related articles - All 6 versions
- ►diabetesjournals.org [PDF] P Wu, K Inskeep, MM Bowker-Kinley, KM … - Diabetes, 1999 - Am Diabetes Assoc Regulation of the activity of the pyruvate dehydrogenase complex in skeletal
muscle plays an important role in fuel selection and glucose homeostasis.
Activation of the complex promotes disposal of glucose, whereas inacti- ... Cited by 162 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] P Wu, J Sato, Y Zhao, J Jaskiewicz, KM Popov … - Biochemical Journal, 1998 - pubmedcentral.nih.gov This study investigated whether conditions known to alter the activity and
phosphorylation state of the pyruvate dehydrogenase complex have specific
effects on the levels of isoenzymes of pyruvate dehydrogenase kinase (PDK) ... Cited by 172 - Related articles - BL Direct - All 8 versions
