JFP Wojtaszewski, SB Jørgensen, Y Hellsten, DG … - Diabetes, 2002 - Am Diabetes Assoc 5′-AMP-activated protein kinase (AMPK) functions as a metabolic switch in mammalian cells
and can be artificially activated by 5-aminoimidazole-4-carboxamide (AICA)-riboside. AMPK
activation during muscle contraction is dependent on muscle glycogen concentrations, ... Cited by 133 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org WG Aschenbach, MF Hirshman, N Fujii, K Sakamoto, … - Diabetes, 2002 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is proposed to stimulate fat and carbohydrate catabolism
to maintain cellular energy status. Recent studies demonstrate that pharmacologic activation
of AMPK and mutations in the enzyme are associated with elevated muscle glycogen ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►cell.com G Polekhina, A Gupta, BJ Michell, B van Denderen, S … - Current Biology, 2003 - Elsevier AMP-activated protein kinase (AMPK) is a multisubstrate enzyme activated by increases in AMP
during metabolic stress caused by exercise, hypoxia, lack of cell nutrients [1], as well as
hormones, including adiponectin and leptin [2] and [3]. Furthermore, metformin and ... Cited by 182 - Related articles - All 13 versions
ER Hudson, DA Pan, J James, JM Lucocq, SA Hawley, … - Current biology, 2003 - Elsevier The AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that is activated by low cellular
energy status and affects a switch away from energy-requiring processes and toward catabolism
[1]. While it is primarily regulated by AMP and ATP, high muscle glycogen has also been ... Cited by 147 - Related articles - All 10 versions
D Carling, DG Hardie - Biochimica et biophysica acta, 1989 - ncbi.nlm.nih.gov In addition to acetyl-CoA carboxylase and HMG-CoA reductase, the AMP-activated protein kinase
phosphorylates glycogen synthase, phosphorylase kinase, hormone-sensitive lipase and
casein. A number of other substrates for the cyclic AMP-dependent protein kinase, eg, L- ... Cited by 140 - Related articles - All 3 versions
… , C MacDonald, JN Nielsen, Y Hellsten, … - American Journal of …, 2003 - Am Physiological Soc The metabolic role of 5'AMP-activated protein kinase (AMPK) in regulation of skeletal muscle
metabolism in humans is unresolved. We measured isoform-specific AMPK activity and
-acetyl-CoA carboxylase (ACC ) Ser 221 phosphorylation and substrate balance in ... Cited by 116 - Related articles - BL Direct - All 4 versions
W Derave, H Aj, J Ihlemann, LA Witters, S … - DIABETES-NEW …, 2000 - Am Diabetes Assoc 5 AMP-activated protein kinase (AMPK) has been sug- gested to be a key regulatory protein
in exercise sig- naling of muscle glucose transport. To test this hypoth- esis, we investigated
whether muscle glycogen levels affect AMPK activation and glucose transport stimula- ... Cited by 126 - Related articles - BL Direct - All 5 versions
JN Nielsen, JFP Wojtaszewski, RG Haller, … - The Journal of …, 2002 - Physiological Soc It has been suggested that 5′AMP-activated protein kinase (AMPK) is involved in the regulation
of glucose and glycogen metabolism in skeletal muscle. We used patients with chronic high muscle
glycogen stores and deficient glycogenolysis (McArdle's disease) as a model to address ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►physoc.org JFP Wojtaszewski, P Nielsen, BF Hansen, EA … - The Journal of …, 2000 - Physiological Soc We investigated the degree of activation and deactivation of α-isoforms of AMPK during and
after exercise. Healthy human subjects performed bicycle exercise on two separate occasions
at either a low (∼50% maximum rate of O 2 uptake (V̇ O 2 ,max ) for 90 min) or a high (∼ ... Cited by 170 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Halse, LGD Fryer, JG McCormack, D Carling, SJ … - Diabetes, 2003 - Am Diabetes Assoc We report here use of human myoblasts in culture to study the relationships between cellular
glycogen concentrations and the activities of glycogen synthase (GS) and AMP-activated protein
kinase (AMPK). Incubation of cells for 2 h in the absence of glucose led to a 25% ... Cited by 50 - Related articles - BL Direct - All 5 versions
