HE Thomas, R Darwiche, JA Corbett, TWH … - Diabetes, 2002 - Am Diabetes Assoc Cytokines have been implicated in pancreatic β-cell destruction leading to type
1 diabetes. In vitro, a combination of γ-interferon (IFN-γ) and interleukin-1
(IL-1) stimulate inducible nitric oxide synthase (iNOS) expression in ... Cited by 76 - Related articles - BL Direct - All 6 versions
HE Thomas, R Darwiche, JA Corbett, TW Kay - Diabetes, 2002 - Am Diabetes Assoc Cytokines have been implicated in pancreatic -cell destruction leading to type 1
diabetes. In vitro, a com- bination of -interferon (IFN- ) and interleukin-1
(IL-1) stimulate inducible nitric oxide synthase (iNOS) expression in ... Cited by 29 - Related articles - All 2 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL Dudek, … - The Journal of Immunology, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell
destruction by direct cytotoxicity, inducing Fas expression, and up-regulating
class I MHC and chemokine expression to increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►jbc.org MR Heitmeier, AL Scarim, JA Corbett - Journal of Biological Chemistry, 1997 - ASBMB The purpose of this study was to evaluate the effects of interferon- (IFN- )
alone and in combination with interleukin 1 (IL-1 ) on inducible nitric-oxide
synthase (iNOS) mRNA and protein expression, nitrite production, and ... Cited by 90 - Related articles - BL Direct - All 5 versions
[CITATION] Cytotoxic role of nitric oxide in diabetes
- ►rupress.org [PDF] JA Corbett, ML McDaniel - Journal of Experimental Medicine, 1995 - jem.rupress.org Summary Cytokines, released in and around pancreatic islets during insulitis,
have been proposed to participate in B-cell destruction associated with
autoimmune diabetes. In this study we have evaluated the hypothesis that ... Cited by 109 - Related articles - All 5 versions
- ►jimmunol.org R Darwiche, MMW Chong, P Santamaria, HE … - The Journal of Immunology, 2003 - Am Assoc Immnol Fas (CD95) is a potential mechanism of pancreatic cell death in type 1 diabetes.
cells do not constitutively express Fas but it is induced by cytokines. The
hypothesis of this study is that Fas expression should be measurable on ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org M Arnush, AL Scarim, MR Heitmeier, CB Kelly, … - The Journal of Immunology, 1998 - Am Assoc Immnol The purpose of this study was to evaluate the effects of resident islet
macrophage activation on ß cell function. Treatment of freshly isolated rat
islets with TNF- and LPS results in a potent inhibition of ... Cited by 83 - Related articles - BL Direct - All 3 versions
MMW Chong, HE Thomas, TWH Kay - Journal of Biological Chemistry, 2002 - ASBMB Suppressor of cytokine signaling-1 (SOCS-1) is a negative regulator of the
Jak-STAT (signal transducer and activator of transcription cytokine) signaling
pathway but may also regulate other pathways. At least in vitro, SOCS-1 ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] M Arnush, MR Heitmeier, AL Scarim, MH … - Journal of Clinical Investigation, 1998 - pubmedcentral.nih.gov Resident macrophages have been suggested to participate in the initiation of
cell damage during the development of autoimmune diabetes. The purpose of this
study was to de- termine if the endogenous production and release of inter- ... Cited by 116 - Related articles - BL Direct - All 6 versions
