- ►diabetesjournals.org W Gurr, R Yavari, L Wen, M Shaw, C Mora, L Christa, … - Diabetes, 2002 - Am Diabetes Assoc Genes overexpressed in pancreatic islets of patients with new-onset type 1 diabetes are potential
candidates for novel disease-related autoantigens. RT-PCR-based subtractive hybridization
was used on islets from a patient who died at the onset of type 1 diabetes, and it identified ... Cited by 28 - Related articles - BL Direct - All 5 versions
W Gurr, M Shaw, Y Li, R Sherwin - Diabetes, 2007 - Am Diabetes Assoc The Reg family of proteins has been studied in the context of growth and regeneration in several
organs including pancreatic islets. We previously suggested that Reg proteins act as autoantigens
in type 1 diabetes, based on evidence that a member of the Reg family (hepatocellular ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►nih.gov E Laurine, X Manival, C Montgelard, C Bideau, JL … - BBA-Gene Structure and …, 2005 - Elsevier Reg proteins are expressed in various organs and are involved in cancers and neurodegenerative
diseases. They display a typical C-type lectin-like domain but possess additional highly conserved
amino acids. By studying human databases and Expressed Sequence Tags library, we ... Cited by 9 - Related articles - All 7 versions
NJ Shervani, S Takasawa, Y Uchigata, T … - European journal of …, 2004 - interscience.wiley.com Background Regenerating gene (Reg) product, Reg, acts as an autocrine/paracrine growth factor
for beta-cell regeneration. The presence of autoimmunity against REG may affect the operative
of the regenerative mechanisms in beta cells of Type 1 and Type 2 diabetes patients. We ... Cited by 9 - Related articles - BL Direct - All 4 versions
S Takasawa, T Ikeda, T Akiyama, K Nata, K Nakagawa, … - FEBS letters, 2006 - Elsevier Regenerating gene product (Reg) is induced in pancreatic β-cells and acts as an autocrine/paracrine
growth factor for regeneration via a cell surface Reg receptor. However, the manner by which
Reg induces β-cell regeneration was unknown. In the present study, we found that Reg ... Cited by 16 - Related articles - All 6 versions
- ►jhc.org D Sanchez, N Baeza, R Blouin, C Devaux, … - … of Histochemistry and …, 2000 - Histochemical Soc Terazono et al., in 1988, isolated a clone from a cDNA library prepared from pancreatic islets
isolated from 90% pancreatectomized nicotinamide-treated rats, a model of islet
regeneration. The gene corresponding to the clone was named reg. This gene was found ... Cited by 16 - Related articles - BL Direct - All 4 versions
M Unno, K Nata, N Noguchi, Y Narushima, T Akiyama, … - Diabetes, 2002 - Am Diabetes Assoc Reg (regenerating gene) was isolated as a gene specifically expressed in regenerating
islets. We have demonstrated in vitro and in vivo that the exogenous addition of rat and human
Reg gene products, Reg/REG proteins, induced β-cell replication via the Reg receptor ... Cited by 51 - Related articles - BL Direct - All 6 versions
K Nata, Y Liu, L Xu, T Ikeda, T Akiyama, N Noguchi, S … - Gene, 2004 - Elsevier Regenerating gene (Reg), first isolated from a regenerating islet cDNA library [J. Biol. Chem.
263 (1988) 2111], encodes a secretory protein with a growth stimulating effect on pancreatic
β cells that ameliorates the diabetes of 90% depancreatized rats [Proc. Natl. Acad. Sci. ... Cited by 20 - Related articles - All 3 versions
N Baeza, D Sanchez, B Vialettes, C Figarella - FEBS letters, 1997 - Elsevier The reg gene, previously described in islets of 90% pancreatectomized and nicotinamide-treated
rats, has been shown to be expressed in many pharmacological or surgical animal models of
beta cell regeneration. We have studied the non-obese diabetic (NOD) mouse, which ... Cited by 21 - Related articles - All 7 versions
- ►endojournals.org DJ Gross, L Weiss, I Reibstein, J van den Brand, H … - Endocrinology, 1998 - Endocrine Soc Oral linomide, (quinoline-3-carboxamide), has been shown to prevent autoimmune insulitis,
islet destruction, and diabetes in NOD mice treated at an early stage of the disease, but confers
only partial protection in animals with advanced disease. Reg protein, the gene product of ... Cited by 47 - Related articles - BL Direct - All 3 versions
