AM Alexander, M Crawford, S Bertera, WA Rudert, O … - Diabetes, 2002 - Am Diabetes Assoc Indoleamine 2,3-dioxygenase (IDO) catalyzes the breakdown of the amino acid tryptophan into
kyneurenine. It has been shown that IDO production by placental trophoblasts prevents the attack
of maternal T-cells activated in response to the paternal HLA alleles expressed by the ... Cited by 121 - Related articles - BL Direct - All 5 versions
SC Beutelspacher, R Pillai, MP Watson, … - European journal of …, 2006 - interscience.wiley.com Indoleamine 2,3-dioxygenase (IDO) suppresses T cell responses by its action in catabolising
tryptophan. It is important in maintenance of immune privilege in the placenta. We investigated
the activity of IDO in the cornea, following corneal transplantation and the effect of IDO ... Cited by 63 - Related articles - BL Direct - All 6 versions
T Miki, H Sun, YH Lee, A Tandin, AM Kovscek, V … - Transplantation …, 2001 - Elsevier In most mouse strain combinations, fully allogeneic liver grafts are accepted without any immunosuppressive
therapy, while the heart and other organs are rejected.[1] Although apoptotic cytotoxic T lymphocytes
are observed in the spontaneously accepted liver allograft, [2] the mechanism of liver ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org AL Mellor, DB Keskin, T Johnson, P … - The Journal of …, 2002 - Am Assoc Immnol Pharmacological inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine gestation
results in fetal allograft rejection and blocks the ability of murine CD8 + dendritic cells to suppress
delayed-type hypersensitivity responses to tumor-associated peptide Ags. These ... Cited by 156 - Related articles - BL Direct - All 3 versions
H Liu, L Liu, BS Fletcher, GA Visner - American journal of respiratory …, 2006 - 171.66.122.149 Page 1. Novel Action of Indoleamine 2,3-Dioxygenase Attenuating Acute Lung Allograft
Injury Hanzhong Liu1, Li Liu2, Bradley S. Fletcher2,3, Gary A. Visner1 Department of
Pediatrics1 and Department of Pharmacology and Therapeutics2, ... Cited by 43 - Related articles - View as HTML - BL Direct - All 8 versions
- ►jimmunol.org P Hwu, MX Du, R Lapointe, M Do, MW Taylor … - The Journal of …, 2000 - Am Assoc Immnol Dendritic cells (DCs) play a key role in the activation and regulation of B and T lymphocytes.
Production of indoleamine 2,3-dioxygenase (IDO) by macrophages has recently been described
to result in inhibition of T cell proliferation through tryptophan degradation. Since DCs can ... Cited by 273 - Related articles - BL Direct - All 4 versions
Y Li, EE Tredget, A Ghaffari, X Lin, RT Kilani, A … - Journal of Investigative …, 2006 - nature.com The expression of indoleamine 2,3-dioxygenase (IDO), which metabolizes tryptophan, an essential
amino acid, into kynurenine, has been identified as having a key role in the prevention of the
immune rejection of the semi-allogeneic fetus during pregnancy. We have previously ... Cited by 27 - Related articles - BL Direct - All 3 versions
G Brandacher, F Cakar, C Winkler, S … - Kidney …, 2007 - kozue.i-med.ac.at The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is activated by
interferon-c (IFN-c) and via tryptophan depletion, suppresses adaptive T cell-mediated immunity
in inflammation, host immune defense, and maternal tolerance. Its role in solid organ ... Cited by 30 - Related articles - View as HTML - BL Direct - All 6 versions
- ►rupress.org P Terness, TM Bauer, L Rose, C Dufter, A … - Journal of Experimental …, 2002 - jem.rupress.org Indoleamine 2,3-dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, is expressed
in certain cells and tissues, particularly in antigen-presenting cells of lymphoid organs and in
the placenta. It was shown that IDO prevents rejection of the fetus during pregnancy, ... Cited by 320 - Related articles - BL Direct - All 7 versions
- ►rupress.org G Frumento, R Rotondo, M Tonetti, G Damonte … - Journal of Experimental …, 2002 - jem.rupress.org Macrophages exposed to macrophage colony-stimulating factor acquire the capacity to suppress
T cell proliferation; this effect is associated with de novo expression of the tryptophan-catabolizing
enzyme indoleamine 2,3-dioxygenase (IDO). We have purified IDO and tested its activity ... Cited by 252 - Related articles - BL Direct - All 6 versions
