- ►diabetesjournals.org P Serradas, L Goya, M Lacorne, MN … - Diabetes, 2002 - Am Diabetes Assoc At late fetal age (21.5 days postcoitum [dpc]), GK rats present a severely
reduced β-cell mass compared with Wistar rats. This anomaly largely antedates
the onset of hyperglycemia in GK rats. Thus, the β-cell mass deficit could ... Cited by 24 - Related articles - BL Direct - All 5 versions
C Plachot, J Movassat, B Portha - Histochemistry and Cell Biology, 2001 - Springer Abstract In the Goto-Kakizaki (GK) rat, a genetic mod- el of type II diabetes,
there is a restriction of the β-cell mass as early as fetal age, which is
maintained reduced in the adult animal. In order to investigate the β-cell ... Cited by 40 - Related articles - BL Direct - All 3 versions
F Miralles, B Portha - Diabetes, 2001 - Am Diabetes Assoc The Goto-Kakisaki (GK) rat is a genetic model of type 2 diabetes obtained by
selective inbreeding of mildly glucose-intolerant Wistar rats. Previous studies
have shown that at birth, the -cell mass of the GK rat is severely reduced ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►endojournals.org DJ Hill, B Strutt, E Arany, S Zaina, S Coukell … - Endocrinology, 2000 - Endocrine Soc In rats, a proportion of pancreatic ß-cells are deleted by apoptosis in the
second week of postnatal life and replaced by endocrine cell neogenesis from
pancreatic ductal epithelium. This coincides with a reduction in pancreatic ... Cited by 41 - Related articles - BL Direct - All 2 versions
S Calderari, MN Gangnerau, M Thibault, MJ … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The Goto–Kakizaki (GK) rat is a spon- taneous model
of type 2 diabetes. Defective beta cell mass detectable in late fetal age
precedes the onset of hyper- glycaemia. Our hypothesis was that an ... Cited by 4 - Related articles - BL Direct - All 4 versions
MH Giroix, C Saulnier, B Portha - Diabetologia, 1999 - Springer One of the major characteristic features of Type II (non-insulin-dependent)
diabetes mellitus is the de- creased ability of pancreatic beta cells to release
insu- lin in response to stimulation by the carbohydrate d-glucose, the ... Cited by 18 - Related articles - BL Direct - All 4 versions
J Movassat, B Portha - Diabetologia, 1999 - Springer Established Type II (non-insulin-dependent) diabe- tes mellitus is associated
with profound insulin secre- tory defects that occur together with insulin
resist- ance. The basis for the insulin secretory defects is not known and ... Cited by 30 - Related articles - BL Direct - All 3 versions
J Movassat, C Saulnier, P Serradas, B Portha - Diabetologia, 1997 - Springer Page 1. Established non-insulin-dependent diabetes melli- tus (NIDDM) is associated
with profound insulin secretorydefectsthatoccurtogetherwithinsulinresis ... Cited by 74 - Related articles - BL Direct - All 3 versions
- ►endojournals.org M Martin, P Serradas, S Ramos, E Fernandez, … - Endocrinology, 2005 - Endocrine Soc We have previously shown that fetuses from protein-caloric undernourished
pregnant rats (35% of control diet during the last week of pregnancy) at 21.5 d
post coitum exhibit increased ß-cell mass. This alteration is correlated ... Cited by 10 - Related articles - All 5 versions
