GC Webb, MS Akbar, C Zhao, HH Swift, DF … - Diabetes, 2002 - Am Diabetes Assoc Prohormone convertase 2 (PC2) plays an essential role in the processing of
proglucagon to mature active glucagon in pancreatic α-cells (J Biol Chem
276:27197–27202, 2001). Mice lacking PC2 demonstrate multiple defects, ... Cited by 34 - Related articles - BL Direct - All 5 versions
JC Parker, KM Andrews, MR Allen, JL Stock, … - Biochemical and Biophysical Research …, 2002 - Elsevier The action of glucagon in the liver is mediated by G-coupled receptors. To
examine the role of glucagon in glucose homeostasis, we have generated mice in
which the glucagon receptor was inactivated (GR −/− mice). Blood ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang, DM … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to
hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated
in the etiology of this condition; however, effective therapies to block ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►endojournals.org M Vincent, Y Guz, M Rozenberg, G Webb, M … - Endocrinology, 2003 - Endocrine Soc To date, the role of pancreatic hormones in pancreatic islet growth and
differentiation is poorly understood. To address this issue, we examined mice
with a disruption in the gene encoding prohormone convertase 2 (PC2). These ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov RW Gelling, XQ Du, DS Dichmann, J Rømer, H … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Glucagon, the counter-regulatory hormone to insulin, is secreted from pancreatic
α cells in response to low blood glucose. To examine the role of glucagon in
glucose homeostasis, mice were generated with a null mutation of the ... Cited by 80 - Related articles - BL Direct - All 7 versions
- ►jbc.org M Furuta, A Zhou, G Webb, R Carroll, M … - Journal of Biological Chemistry, 2001 - ASBMB Mice homozygous for a deletion in the gene encoding prohormone convertase 2
(PC2) are generally healthy but have mild hypoglycemia and flat
glucose-tolerance curves. Their islets show marked alpha (A)-cell ... Cited by 66 - Related articles - BL Direct - All 3 versions
Y Liang, MC Osborne, BP Monia, S Bhanot, … - Diabetes, 2004 - Am Diabetes Assoc Excess glucagon levels contribute to the hyperglycemia associated with type 2
diabetes. Reducing glucagon receptor expression may thus ameliorate the
consequences of hyperglucagonemia and improve blood glucose control in ... Cited by 47 - Related articles - BL Direct - All 5 versions
KF Petersen, JT Sullivan - Diabetologia, 2001 - Springer Fasting hyperglycaemia in patients with poorly con- trolled Type II
(non-insulin-dependent) diabetes mellitus is closely associated with increased
rates of glucose production which in turn can be ascribed to increased ... Cited by 62 - Related articles - BL Direct - All 3 versions
CL Brand, PN Jørgensen, I Svendsen, JJ … - Diabetes, 1996 - Am Diabetes Assoc Effects of glucagon immunoneutralization on plasma glucose, insulin, and
glucagon were studied 2-4 h after intravenous injection of a high-affinity,
monoclonal glucagon antibody into normal as well as moderately and severely ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►endojournals.org PM Vuguin, MH Kedees, L Cui, Y Guz, RW … - Endocrinology, 2006 - Endocrine Soc Although glucagon (GLU) plays a pivotal role in glucose homeostasis, its role in
the regulation of fetal growth and maturation is poorly understood. These issues
were examined in a line of mice with a global deletion of the GLU receptor ... Cited by 14 - Related articles - BL Direct - All 4 versions
