DR Laybutt, H Kaneto, W Hasenkamp, S Grey, … - Diabetes, 2002 - Am Diabetes Assoc Hypertrophy is one mechanism of pancreatic β-cell growth and is seen as an
important compensatory response to insulin resistance. We hypothesized that the
induction of protective genes contributes to the survival of enlarged ( ... Cited by 112 - Related articles - BL Direct - All 5 versions
JC Jonas, Y Guiot, J Rahier, JC Henquin - Diabetologia, 2003 - Springer Aim/hypothesis. Increased expression of haeme-oxyge- nase 1 (HO1) and other
antioxidant enzymes could im- prove pancreatic beta-cell survival under
stressful condi- tions, including hyperglycaemia. However, how hyper- ... Cited by 20 - Related articles - BL Direct - All 5 versions
DR Laybutt, M Glandt, G Xu, YB Ahn, N … - Journal of Biological Chemistry, 2003 - ASBMB We have proposed that hyperglycemia-induced dedifferentiation of -cells is a
critical factor for the loss of insulin secretory function in diabetes. Here we
examined the effects of the duration of hyperglycemia on gene expression in ... Cited by 69 - Related articles - BL Direct - All 4 versions
- ►jbc.org DR Laybutt, A Sharma, DC Sgroi, J Gaudet, S … - Journal of Biological Chemistry, 2002 - ASBMB In models of type 2 diabetes the expression of -cell genes is altered, but these
changes have not fully explained the impairment in -cell function. We
hypothesized that changes in -cell phenotype and global alterations in both ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►jbc.org JC Jonas, DR Laybutt, GM Steil, N Trivedi, … - Journal of Biological Chemistry, 2001 - ASBMB Glucose-induced insulin secretion from hyperglycemic 90% pancreatectomized rats
is markedly impaired, possibly because of loss of cell differentiation.
Association of these changes with cell hypertrophy, increased mRNA levels ... Cited by 64 - Related articles - BL Direct - All 5 versions
JC Jonas, A Sharma, W Hasenkamp, H Ilkova, … - Journal of Biological Chemistry, 1999 - ASBMB Differentiated pancreatic β cells are unique in their ability to secrete
insulin in response to a rise in plasma glucose. We have proposed that the
unique constellation of genes they express may be lost in diabetes due to ... Cited by 273 - Related articles - BL Direct - All 4 versions
Y Ihara, S Toyokuni, K Uchida, H Odaka, T … - Diabetes, 1999 - Am Diabetes Assoc Reactive oxygen species are involved in a diversity of biological phenomena such
as inflammation, carcinogenesis, aging, and atherosclerosis. We and other
investigators have shown that the level of 8-hydroxy-2'-deoxyguanosine ... Cited by 185 - Related articles - BL Direct - All 7 versions
- ►pnas.org Y Tanaka, CE Gleason, POT Tran, JS Harmon … - Proceedings of the National Academy of Sciences, 1999 - National Acad Sciences Chronic exposure of pancreatic islets to supraphysiologic concentrations of
glucose causes adverse alterations in β cell function, a phenomenon termed
glucose toxicity and one that may play a secondary pathogenic role in type ... Cited by 206 - Related articles - BL Direct - All 10 versions
M Tiedge, S Lortz, J Drinkgern, S Lenzen - Diabetes, 1997 - Am Diabetes Assoc Antioxidant enzyme expression was determined in rat pancreatic islets and RINm5F
insulin-producing cells on the level of mRNA, protein, and enzyme activity in
comparison with 11 other rat tissues. Although superoxide dismutase ... Cited by 333 - Related articles - BL Direct - All 6 versions
- ►endojournals.org J Ye, SG Laychock - Endocrinology, 1998 - Endocrine Soc Heme oxygenase (HO)-1 expression was investigated in rat isolated pancreatic
islets. Freshly isolated islets showed no evidence of HO-1 expression. After a
20-h culture, there was a small increase in HO-1 in control islets, and ... Cited by 74 - Related articles - BL Direct - All 4 versions
