YB Kim, TP Ciaraldi, A Kong, D Kim, N Chu, … - Diabetes, 2002 - Am Diabetes Assoc Insulin stimulation of phosphatidylinositol (PI) 3-kinase activity is defective
in skeletal muscle of type 2 diabetic individuals. We studied the impact of
antidiabetic therapy on this defect in type 2 diabetic subjects who failed ... Cited by 68 - Related articles - BL Direct - All 4 versions
TP Ciaraldi, APS Kong, NV Chu, DD Kim, S … - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetic subjects failing glyburide therapy were randomized to receive
additional therapy with either metformin (2,550 mg/day) or troglitazone (600
mg/day) for 3–4 months. Biopsies of subcutaneous abdominal adipose tissue ... Cited by 67 - Related articles - BL Direct - All 4 versions
Y Miyazaki, H He, LJ Mandarino, RA … - Diabetes, 2003 - Am Diabetes Assoc Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in
patients with type 2 diabetes. To determine whether the TZD-induced improvement
in glycemic control is associated with enhanced insulin receptor signaling ... Cited by 74 - Related articles - BL Direct - All 8 versions
MM Meyer, K Levin, T Grimmsmann, N Perwitz, … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether the effect of troglitazone on glucose disposal is
associated with altered insulin signaling. Nondiabetic first-degree relatives of
type 2 diabetic patients (age 30 ± 2 years, BMI 30 ± 1 kg/m 2 ; n = 20) ... Cited by 28 - Related articles - BL Direct - All 4 versions
JE Gunton, PJD Delhanty, SI Takahashi, RC … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Metformin decreases endogenous glucose production by the liver. Few studies have
examined the effect of metformin on the insulin-signaling pathway in liver
models, and none have presented data on the effect in normal human liver. ... Cited by 34 - Related articles - BL Direct - All 5 versions
- ►nih.gov YB Kim, SE Nikoulina, TP Ciaraldi, RR Henry … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig To determine whether the serine/threonine kinase Akt (also known as protein
kinase B) is activated in vivo by insulin administration in humans, and whether
impaired activation of Akt could play a role in insulin resistance, we ... Cited by 262 - Related articles - BL Direct - All 10 versions
D Galuska, LA Nolte, JR Zierath, H Wallberg- … - Diabetologia, 1994 - Springer Summary Metformin has been demonstrated to lower blood glucose in vivo by a
mechanism which increases peripheral glucose uptake. Furthermore, the ther-
apeutic concentration of metformin has been esti- mated to be in the order ... Cited by 44 - Related articles - BL Direct - All 3 versions
M Björnholm, Y Kawano, M Lehtihet, JR … - Diabetes, 1997 - Am Diabetes Assoc We examined the effect of physiological hyperinsulinemia on insulin receptor
substrate-1 (IRS-1) tyrosine phosphorylation and phosphatidylinositol (PI)
3-kinase activity in skeletal muscle from six lean-to-moderately obese ... Cited by 238 - Related articles - BL Direct - All 3 versions
[CITATION] Effect of rosiglitazone on glucose and free fatty acid metabolism in type 2 diabetic patients
M Beeson, MP Sajan, M Dizon, D Grebenev, J … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose
transport in skeletal muscle. Atypical protein kinase C (aPKC) and protein
kinase B (PKB), operating downstream of phosphatidylinositol (PI) 3-kinase ... Cited by 90 - Related articles - BL Direct - All 4 versions
