- ►inotekcorp.com [PDF] P Pacher, L Liaudet, FG Soriano, JG Mabley, … - Diabetes, 2002 - Am Diabetes Assoc Patients with diabetes exhibit a high incidence of diabetic cardiomyopathy and
vascular complications, which underlie the development of retinopathy,
nephropathy, and neuropathy and increase the risk of hypertension, stroke, ... Cited by 144 - Related articles - BL Direct - All 9 versions
- ►ahajournals.org FG Soriano, P Pacher, J Mabley, L Liaudet, C … - Circulation research, 2001 - Am Heart Assoc Abstract—— Oxygen- and nitrogen-derived free radicals and oxidants play an
important role in the pathogenesis of diabetic endothelial dysfunction. Recently
we proposed the importance of oxidant-induced DNA strand breakage and ... Cited by 125 - Related articles - BL Direct - All 10 versions
- ►onlinejacc.org P Pacher, L Liaudet, JG Mabley, K Komjáti, C … - Journal of the American College of Cardiology, 2002 - Elsevier We investigated the effects of a novel ultrapotent poly(adenosine
diphosphate-ribose) polymerase (PARP) inhibitor, PJ34, on cardiac and
endothelial dysfunction in a rat model of chronic heart failure (CHF). Cited by 68 - Related articles - BL Direct - All 16 versions
FG Soriano, L Virág, P Jagtap, E Szabo, JG … - Nature medicine, 2001 - inotekcorp.com Poly(ADP ribose) polymerase (PARP) is a profuse nuclear enzyme of eukaryotic
cells that has been implicated in response to DNA injury. Free-radical- and
oxidant-induced cell injury can involve the activa- tion of PARP. When ... Cited by 340 - Related articles - View as HTML - BL Direct - All 9 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ... Cited by 87 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org C Szabo, A Zanchi, K Komjati, P Pacher, AS … - Circulation, 2002 - Am Heart Assoc Methods and Results— We included a control group of 21 healthy subjects, a
group of 22 healthy individuals with parental history of type 2 diabetes, a
group of 23 subjects with impaired glucose tolerance, and a group of 21 ... Cited by 90 - Related articles - BL Direct - All 11 versions
- ►nih.gov X Du, T Matsumura, D Edelstein, L Rossetti, Z … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig In this report, we show that hyperglycemia-induced overproduction of superoxide
by the mitochondrial electron transport chain activates the three major pathways
of hyperglycemic damage found in aortic endothelial cells by inhibiting ... Cited by 290 - Related articles - BL Direct - All 11 versions
L Zheng, C Szabó, TS Kern - Diabetes, 2004 - Am Diabetes Assoc The current study investigated the role of poly(ADP-ribose) polymerase (PARP) in
the development of diabetic retinopathy. Activity of PARP was increased in whole
retina and in endothelial cells and pericytes of diabetic rats. ... Cited by 98 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org P Pacher, L Liaudet, P Bai, L Virag, JG … - Journal of Pharmacology and Experimental …, 2002 - ASPET Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) by
oxidant-mediated DNA damage is an important pathway of cell dysfunction and
tissue injury in conditions associated with oxidative stress. Increased ... Cited by 91 - Related articles - BL Direct - All 6 versions
P Pacher, A Cziráki, JG Mabley, L Liaudet, L … - Biochemical pharmacology, 2002 - Elsevier Reactive oxygen and nitrogen species are overproduced in the cardiovascular
system during circulatory shock. Oxidant-induced cell injury involves the
activation of poly(ADP-ribose) polymerase (PARP). Using a dual approach of ... Cited by 37 - Related articles - All 6 versions
