- ►diabetesjournals.org WG Aschenbach, MF Hirshman, N Fujii, K Sakamoto, … - Diabetes, 2002 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is proposed to stimulate fat and carbohydrate catabolism
to maintain cellular energy status. Recent studies demonstrate that pharmacologic activation
of AMPK and mutations in the enzyme are associated with elevated muscle glycogen ... Cited by 52 - Related articles - BL Direct - All 5 versions
JFP Wojtaszewski, SB Jørgensen, Y Hellsten, DG … - Diabetes, 2002 - Am Diabetes Assoc 5′-AMP-activated protein kinase (AMPK) functions as a metabolic switch in mammalian cells
and can be artificially activated by 5-aminoimidazole-4-carboxamide (AICA)-riboside. AMPK
activation during muscle contraction is dependent on muscle glycogen concentrations, ... Cited by 133 - Related articles - BL Direct - All 6 versions
D Carling, DG Hardie - Biochimica et biophysica acta, 1989 - ncbi.nlm.nih.gov In addition to acetyl-CoA carboxylase and HMG-CoA reductase, the AMP-activated protein kinase
phosphorylates glycogen synthase, phosphorylase kinase, hormone-sensitive lipase and
casein. A number of other substrates for the cyclic AMP-dependent protein kinase, eg, L- ... Cited by 140 - Related articles - All 3 versions
- ►physiology.org SL Longnus, RB Wambolt, HL Parsons, … - American Journal of …, 2003 - Am Physiological Soc We tested the hypothesis that activation of AMP-activated protein kinase (AMPK) promotes myocardial
glycogenolysis by decreasing glycogen synthase (GS) and/or increasing glycogen phosphorylase
(GP) activities. Isolated working hearts from halothane-anesthetized male ... Cited by 54 - Related articles - BL Direct - All 3 versions
- ►physiology.org EO Ojuka, LA Nolte, JO Holloszy - Journal of Applied Physiology, 2000 - Am Physiological Soc Exercise acutely stimulates muscle glucose transport and also brings about an adaptive increase
in the capacity of muscle for glucose uptake by inducing increases in GLUT-4 and
hexokinase. 1 Recent studies have provided evidence that activation of AMP protein ... Cited by 98 - Related articles - BL Direct - All 3 versions
A Beyer, A Kitzerow, B Crute, BE Kemp, LA … - Biological …, 2000 - reference-global.com AMP-activated protein kinase (AMPK) and cAMP-de- pendent protein kinase (cAMPK) have been
reported to phosphorylate sites on phosphorylase kinase (PhK). Their target residues Ser 1018
and Ser 1020, respec- tively, are located in the so-called multi-phosphoryla- tion domain ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Halse, LGD Fryer, JG McCormack, D Carling, SJ … - Diabetes, 2003 - Am Diabetes Assoc We report here use of human myoblasts in culture to study the relationships between cellular
glycogen concentrations and the activities of glycogen synthase (GS) and AMP-activated protein
kinase (AMPK). Incubation of cells for 2 h in the absence of glucose led to a 25% ... Cited by 50 - Related articles - BL Direct - All 5 versions
J Mu, E Barton, M Birnbaum - Biochemical Society Transactions, 2003 - bst.portlandpress.com AMP-activated protein kinase (AMPK) is becoming recognized as a critical regulator of energy
metabolism in cells. Using a mouse model in which we specifically blocked AMPK activity in
muscles, we have demonstrated that activation of AMPK is necessary for the effects of 5- ... Cited by 54 - Related articles - Cached - BL Direct - All 9 versions
SA Habinowski, M Hirshman, K Sakamoto, BE … - Archives of Biochemistry …, 2001 - Elsevier The AMP-activated protein kinase (AMPK) plays an important role in fuel metabolism in exercising
skeletal muscle and possibly in the islet cell with respect to insulin secretion. Some of these effects
are due to AMPK-mediated regulation of cellular malonyl-CoA content, ascribed to the ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►physiology.org N Musi, T Hayashi, N Fujii, MF Hirshman, … - American Journal of …, 2001 - Am Physiological Soc The AMP-activated protein kinase (AMPK) has been hypothesized to mediate contraction and
5-aminoimidazole-4-carboxamide 1- -D-ribonucleoside (AICAR)-induced increases in glucose
uptake in skeletal muscle. The purpose of the current study was to determine whether ... Cited by 132 - Related articles - BL Direct - All 3 versions
