M Hawkins, I Gabriely, R Wozniak, C Vilcu, H Shamoon … - Diabetes, 2002 - Am Diabetes Assoc The ability of hyperglycemia per se to suppress endogenous glucose production (GP) is blunted in
type 2 diabetes. This could be due in part to decreased glucose-induced flux through glucokinase
(GK). Because fructose activates ... Cited by 41 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org KF Petersen, D Laurent, C Yu, GW Cline, GI Shulman - Diabetes, 2001 - Am Diabetes Assoc Fructose has been shown to have a catalytic effect on glucokinase activity in vitro; however, its
effects on hepatic glycogen metabolism in humans is unknown. To address this question, we used 13 C
nuclear magnetic resonance (NMR) ... Cited by 35 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org MC Moore, SN Davis, SL Mann, AD Cherrington - Diabetes Care, 2001 - Am Diabetes Assoc RESULTS—The area under the curve (AUC) of the plasma glucose response was reduced by fructose
administration in all subjects; the mean AUC during the OGTT + F was 14% less than that during the
OGTT – F (P < 0.05). The insulin ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] M Shiota, P Galassetti, M Monohan, DW Neal, AD … - Diabetes, 1998 - Am Diabetes Assoc Fructose activates glucokinase by releasing the enzyme from its inhibitory protein in liver. To
examine the impor- tance of acute activation of glucokinase in regulating hepatic glucose uptake,
the effect of intraportal infusion ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Shiota, MC Moore, P Galassetti, M Monohan, DW … - Diabetes, 2002 - Am Diabetes Assoc Intraportal infusion of small amounts of fructose markedly augmented net hepatic glucose uptake
(NHGU) during hyperglycemic hyperinsulinemia in conscious dogs. In this study, we examined whether
the inclusion of catalytic amounts ... Cited by 28 - Related articles - BL Direct - All 6 versions
- ►endojournals.org MC Moore, AD Cherrington, SL Mann, SN … - Journal of Clinical …, 2000 - Endocrine Soc In animal models, a small (catalytic) dose of fructose administered with glucose decreases the
glycemic response to the glucose load. Therefore, we examined the effect of fructose on glucose
tolerance in 11 healthy human ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Aiston, B Andersen, L Agius - Diabetes, 2003 - Am Diabetes Assoc High glucose concentration suppresses hepatic glycogenolysis by allosteric inhibition and
dephosphorylation (inactivation) of phosphorylase-a. The latter effect is attributed to a direct
effect of glucose on the ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Hawkins, I Gabriely, R Wozniak, K Reddy, L Rossetti, … - Diabetes, 2002 - Am Diabetes Assoc Glucose effectiveness is impaired in type 2 diabetes. We hypothesize that chronic hyperglycemia and
hyperlipidemia contribute importantly to this defect. To test this hypothesis, we compared the
effect of acute hyperglycemia on ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] L Agius, M Stubbs - Biochemical Journal, 2000 - pubmedcentral.nih.gov Glucokinase translocates between the cytoplasm and nucleus of hepatocytes where it is bound to a 68
kDa protein. The mech- anism by which glucose induces translocation of glucokinase from the nucleus
was investigated using glucose ... Cited by 30 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] M Mevorach, A Giacca, Y Aharon, M … - Journal of Clinical …, 1998 - pubmedcentral.nih.gov We examined the ability of an equivalent increase in circu- lating glucose concentrations to inhibit
endogenous glucose production (EGP) and to stimulate glucose metabolism in patients with Type 2
diabetes mellitus (DM2). ... Cited by 74 - Related articles - BL Direct - All 10 versions
