A Rabinovitch, WL Suarez-Pinzon, AM Shapiro, RV … - Diabetes, 2002 - Am Diabetes Assoc Sirolimus is an immunosuppressant that inhibits interleukin (IL)-2 signaling of T-cell proliferation
but not IL-2-induced T-cell apoptosis. Therefore, we hypothesized that administration of IL-2,
together with sirolimus, might shift T-cell proliferation to apoptosis and prevent ... Cited by 44 - Related articles - BL Direct - All 6 versions
N Powell, S Till, J Bungre, C Corrigan - The Journal of Allergy and Clinical …, 2001 - Elsevier We have used an optimized, physiologically relevant in vitro assay system to show that in a
concentration-dependent fashion the immunomodulatory drugs cyclosporin A, mycophenolate
mofetil, and sirolimus (rapamycin), as well as the glucocorticoid dexamethasone, inhibit ... Cited by 24 - Related articles - BL Direct - All 8 versions
AMJ Shapiro, WL Suarez-Pinzon, R Power, A … - Diabetologia, 2002 - Springer Type I (insulin-dependent) diabetes mellitus is the re- sult of the selective destruction of pancreatic
islet beta cells by an autoimmune process. A variety of ... Combination therapy with low dose
sirolimus and tacrolimus is ... AMJShapiro 1 , WLSuarez-Pinzon 2 , R.Power 3 , A. ... Cited by 41 - Related articles - BL Direct - All 5 versions
LM Warner, LM Adams, JY Chang, SN Sehgal - Clinical Immunology and …, 1992 - Elsevier Rapamycin, a novel macrocyclic immunosuppressive agent, suppresses murine T cell activation
in vitro by mechanisms distinct from cycloporin A (CsA). This study was designed to examine
rapamycin and CsA in the host vs graft popliteal lymph node (PLN) model, an in vivo ... Cited by 3 - Related articles - All 3 versions
- ►nih.gov [PDF] WL Baeder, J Sredy, SN Sehgal, JY … - Clinical and …, 1992 - pubmedcentral.nih.gov SUMMARY The effect of the immunosuppressive agent rapamycin (RAPA) was assessed in
the non-obese diabetic (NOD) mouse which is an autoimmune model of IDDM. RAPA was prepared
in a vehicle of 8% cremophor EL/2% ethanol and investigated in two studies. NOD/MrK ... Cited by 51 - Related articles - All 4 versions
- ►diabetesjournals.org T Pearson, TG Markees, LS Wicker, DV Serreze, LB … - Diabetes, 2003 - Am Diabetes Assoc The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves
at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral
transplantation tolerance induced by costimulation blockade using donor-specific ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org RD Molano, T Berney, H Li, P Cattan, A Pileggi, C … - Diabetes, 2001 - Am Diabetes Assoc Allorejection and recurrence of autoimmunity are the major barriers to transplantation of islets
of Langerhans for the cure of type 1 diabetes in humans. CD40-CD154 (CD40 ligand) interaction
blockade by the use of anti-CD154 monoclonal antibody (mAb) has shown efficacy in ... Cited by 76 - Related articles - BL Direct - All 4 versions
RD Molano, A Pileggi, T Berney, R Poggioli, E Zahr, … - Transplantation, 2003 - journals.lww.com 25. Schmoeckel M, Bhatti FN, Zaidi A, et al. Orthotopic heart transplantation in a transgenic
pig-to-primate model [published erratum appears in Transplantation 1998; 66(7): 94]. Transplantation
1998; 65: 1570. 26. Ramirez P, Chavez R, Majado M, et al. Life-supporting human ... Cited by 24 - Related articles - BL Direct - All 3 versions
