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Scholar Results 1 - 10 of about 101 related to Hinke: Dipeptidyl peptidase IV-resistant [D-Ala2] glucose-dependent insulinotropic polypeptide.... (0.08 sec) 

Dipeptidyl peptidase IV-resistant [D-Ala2] glucose-dependent insulinotropic polypeptide ( …


SA Hinke, RW Gelling, RA Pederson, S … - Diabetes, 2002 - Am Diabetes Assoc
The therapeutic potential of glucose-dependent insulinotropic polypeptide (GIP)
for improving glycemic control has largely gone unstudied. A series of synthetic
GIP peptides modified at the NH 2 -terminus were screened in vitro for ...
Cited by 57 - Related articles - BL Direct - All 6 versions

Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric …

- endocrinology-journals.org [PDF] 
FP O'Harte, MH Mooney, CM Kelly, PR Flatt - Journal of Endocrinology, 2000 - Soc Endocrinology
Gastric inhibitory polypeptide (GIP) is an important insulin-releasing hormone
of the enteroinsular axis which is rapidly inactivated by the exopeptidase
dipeptidyl peptidase (DPP) IV. The present study has examined the ability ...
Cited by 42 - Related articles - BL Direct - All 10 versions

Improved biological activity of Gly2-and Ser2-substituted analogues of glucose-dependent …

- endocrinology-journals.org [PDF] 
VA Gault, PR Flatt, P Harriott, MH Mooney, CJ … - Journal of Endocrinology, 2003 - Soc Endocrinology
The therapeutic potential of glucagon-like peptide-1 (GLP-1) in improving
glycaemic control in diabetes has been widely studied, but the potential
beneficial effects of glucose-dependent insulinotropic polypeptide (GIP) ...
Cited by 25 - Related articles - BL Direct - All 8 versions

Identification of a bioactive domain in the amino-terminus of glucose-dependent …

- cyclicamp.ca [PDF] 
SA Hinke, S Manhart, N Pamir, HU Demuth, R … - Biochimica et Biophysica Acta (BBA)/Protein …, 2001 - Elsevier
The incretins are a class of hormones released from the small bowel that act on
the endocrine pancreas to potentiate insulin secretion in a glucose-dependent
manner. Due to the requirement for an elevated glucose concentration for ...
Cited by 31 - Related articles - All 3 versions

Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for …

- diabetica.co.uk [PDF] 
VA Gault, PR Flatt, FPM O'Harte - Biochemical and Biophysical Research …, 2003 - Elsevier
Glucose-dependent insulinotropic polypeptide (GIP) is a key incretin hormone,
released postprandially into the circulation in response to feeding, producing a
glucose-dependent stimulation of insulin secretion. It is this glucose- ...
Cited by 55 - Related articles - All 7 versions

Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl …

- cyclicamp.ca [PDF] 
K Kuhn-Wache, S Manhart, T Hoffmann, SA … - Advances in Experimental Medicine and Biology, 2000 - Springer
The incretin GIF (glucose-dependent insulinotropic polypeptide), a 42 amino acid
peptide, is released from the K-cells of the small intestine into the blood in
response to oral nutrient ingestion. GIP inhibits the secretion of gastric ...
Cited by 17 - Related articles - BL Direct - All 3 versions

NH2-terminally modified gastric inhibitory polypeptide exhibits amino-peptidase resistance …

- diabetesjournals.org [PDF] 
FP O'Harte, MH Mooney, PR Flatt - Diabetes, 1999 - Am Diabetes Assoc
Gastric inhibitory polypeptide (GIP) is an important insulin-releasing hormone
of the enteroinsular axis that, like glucagon-like peptide 1(7-36) amide
(tGLP-1), has a functional profile of possible therapeutic value for type 2 ...
Cited by 47 - Related articles - BL Direct - All 4 versions

[CITATION] Enhanced cyclic AMP generation and insulin-releasing potency of two novel N-terminal Tyr1- …


VA Gault, PR Flatt, CJ Bailey, P Harriott, B … - Biochem J, 2002
Cited by 16 - Related articles

Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, …

- endocrinology-journals.org [PDF] 
VA Gault, JC Parker, P Harriott, PR Flatt, FP O … - Journal of Endocrinology, 2002 - Soc Endocrinology
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) is
rapidly degraded in the circulation by dipeptidyl peptidase IV forming the
N-terminally truncated peptide GIP(3–42). The present study exam- ined ...
Cited by 57 - Related articles - BL Direct - All 5 versions

DPP IV resistance and insulin releasing activity of a novel di-substituted analogue of …

- diabetica.co.uk [PDF] 
VA Gault, N Irwin, P Harriott, PR Flatt, FPM O' … - Cell Biology International, 2003 - Elsevier
Structure–function studies suggest that preservation of the N-terminus and
secondary structure of glucose-dependent insulinotropic polypeptide (GIP) is
important for biological activity. Therefore, a novel di-substituted ...
Cited by 20 - Related articles - BL Direct - All 4 versions


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