- ►diabetesjournals.org I Briaud, CL Kelpe, LM Johnson, POT Tran, V Poitout - Diabetes, 2002 - Am Diabetes Assoc Chronic elevations in plasma levels of fatty acids (FAs) adversely affect pancreatic β-cell function
in type 2 diabetes. In vitro, we have previously shown that deleterious effects of prolonged exposure
of isolated islets to FAs were dependent on the presence of elevated glucose ... Cited by 50 - Related articles - BL Direct - All 7 versions
S Jacqueminet, I Briaud, C Rouault, G Reach, V Poitout - Metabolism, 2000 - Elsevier Long-term exposure of pancreatic β cells to elevated levels of fatty acids (FAs) impairs
glucose-induced insulin secretion.However, the effects of FAs on insulin gene expression are
controversial. We hypothesized that FAs adversely affect insulin gene expression only in ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JS Harmon, CE Gleason, Y Tanaka, V Poitout, RP … - Diabetes, 2001 - Am Diabetes Assoc Type 2 diabetes is caused by a combination of β-cell dysfunction and insulin resistance. Over
time, hyperglycemia worsens, a phenomenon that has been attributed to deleterious effects of
chronic hyperglycemia (glucotoxicity) or chronic hyperlipidemia (lipotoxicity) on β-cell ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org I Briaud, JS Harmon, CL Kelpe, VBG Segu, V Poitout - Diabetes, 2001 - Am Diabetes Assoc Prolonged exposure of isolated islets to supraphysiologic concentrations of palmitate decreases
insulin gene expression in the presence of elevated glucose levels. This study was designed
to determine whether or not this phenomenon is associated with a glucose-dependent ... Cited by 139 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Dolz, D Bailbé, MH Giroix, S Calderari, MN … - Diabetes, 2005 - Am Diabetes Assoc Because acetylcholine (ACh) is a recognized potentiator of glucose-stimulated insulin release
in the normal β-cell, we have studied ACh's effect on islets of the Goto-Kakizaki (GK) rat, a spontaneous
model of type 2 diabetes. We first verified that ACh was able to restore the insulin ... Cited by 10 - Related articles - BL Direct - All 6 versions
CL Kelpe, LM Johnson, V Poitout - Endocrinology, 2002 - Endocrine Soc The mechanisms by which prolonged exposure to elevated levels of fatty acids (FA) adversely
affects pancreatic ß-cell function remain unclear. Studies in the Zucker diabetic fatty rat have
suggested that excessive accumulation of triglycerides (TG) in islets plays a key role in ... Cited by 37 - Related articles - BL Direct - All 5 versions
MH Giroix, C Saulnier, B Portha - Diabetologia, 1999 - Springer One of the major characteristic features of Type II (non-insulin-dependent) diabetes mellitus is
the de- creased ability of pancreatic beta cells to release insu- lin in response to stimulation by
the carbohydrate d-glucose, the most potent physiological insulin se- cretagogue. Such a ... Cited by 18 - Related articles - BL Direct - All 4 versions
JW Joseph, V Koshkin, CY Zhang, J Wang, BB Lowell, … - Diabetes, 2002 - Am Diabetes Assoc Uncoupling protein 2 (UCP2) may act as an important regulator of insulin secretion. In this
study, β-cell function in UCP2-deficient mice was examined after a 45% high-fat diet (HFD) to
assess its role during the development of diet-induced type 2 diabetes. HFD-fed UCP2 ... Cited by 120 - Related articles - BL Direct - All 5 versions
CB Chan, PE MacDonald, MC Saleh, DC Johns, E … - Diabetes, 1999 - Am Diabetes Assoc Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by metabolic
conditions such as obesity in humans, but its functional significance is unknown. The expression
of UCP-2 mRNA and protein in normal rat islets was established by reverse tran- ... Cited by 165 - Related articles - BL Direct - All 6 versions
- ►endojournals.org B Ritz-Laser, P Meda, I Constant, N Klages, A … - Endocrinology, 1999 - Endocrine Soc Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance
and to alter the ß-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin
gene expression, we measured insulin release, cell content, and messenger RNA ... Cited by 62 - Related articles - BL Direct - All 5 versions
