H Kim, JY Cha, SY Kim, J Kim, KJ Roh, JK … - Diabetes, 2002 - Am Diabetes Assoc Thiazolidinediones, synthetic ligands of peroxisomal proliferator-activated
receptor-γ (PPAR-γ), improve peripheral insulin sensitivity and
glucose-stimulated insulin secretion in pancreatic β-cells. To explore the ... Cited by 61 - Related articles - BL Direct - All 6 versions
H Kim, J Kim, SH Kim, JY Cha, K Kim, Y Ahn - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc We identified the peroxisomal proliferator response element (PPRE) in the
+68/+89 region of the rat GLUT2 gene. To identify whether the putative PPRE in
the GLUT2 gene (GLUT2-PPRE) is functional, GLUT2 pro- moter-luciferase ... Cited by 77 - Related articles - BL Direct - All 6 versions
M Dubois, F Pattou, J Kerr-Conte, V Gmyr, B … - Diabetologia, 2000 - Springer Apart from its effects on peripheral insulin resis- tance, the first
thiazolidinedione to be approved for clinical use, troglitazone, has been shown
to restore the beta-cell response to an oscillatory glucose infu- sion, to ... Cited by 131 - Related articles - BL Direct - All 4 versions
- ►nih.gov ED Rosen, RN Kulkarni, P Sarraf, U Ozcan, … - Molecular and Cellular Biology, 2003 - Am Soc Microbiol The nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR )
is an important regulator of lipid and glucose homeostasis and cellular
differentiation. Studies of many cell types in vitro and in vivo have ... Cited by 77 - Related articles - BL Direct - All 4 versions
S Kim, H Kim, SK Park, SS Im, T Li, HG Cheon … - Diabetes, 2004 - Am Diabetes Assoc Thiazolidinediones (TZDs), synthetic ligands of peroxisome
proliferator-activated receptor (PPAR)-γ, are known to decrease hepatic glucose
production and increase glycogen synthesis in diabetic animals. Recently it ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►physiology.org LE Parton, F Diraison, SE Neill, SK Ghosh, MA … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Peroxisome proliferator-activated receptor- (PPAR ) serves as a target for the
thiazolidinedione class of antidiabetic drugs and is an important regulator of
adipose tissue differentiation. By contrast, the principal target genes for ... Cited by 29 - Related articles - All 4 versions
H Kim, Y Ahn - Diabetes, 2004 - Am Diabetes Assoc Type 2 diabetes develops in the context of both insulin resistance and β-cell
failure. Thiazolidinediones are a class of antidiabetic agents that are known to
improve insulin sensitivity in various animal models of diabetes. The ... Cited by 29 - Related articles - BL Direct - All 7 versions
- ►yonsei.ac.kr [PDF] H Kim, YK Koh, TH Kim, SK Kwon, SS Im, HS … - Biochemical and biophysical research communications, 2007 - Elsevier The mechanism of how PPARγ decrease gluconeogenic gene expressions in liver is
still unclear. Since PPARγ is a transcriptional activator, it requires a
mediator to decrease the transcription of gluconeogenic genes. Recently, ... Cited by 9 - Related articles - All 7 versions
Y Nakamichi, T Kikuta, E Ito, M Ohara- … - Biochemical and Biophysical Research …, 2003 - Elsevier Peroxisome proliferator-activated receptor-γ (PPAR-γ) regulates several
cellular functions; however, its physiological role in pancreatic β cell
functions remains to be determined. In the present study, we investigated ... Cited by 12 - Related articles - All 4 versions
- ►nih.gov M Higa, YT Zhou, M Ravazzola, D Baetens, L … - Proceedings of the National Academy of Sciences of …, 1999 - National Acad Sciences To determine whether the antidiabetic action of troglitazone (TGZ), heretofore
attributed to insulin sensitization, also involves protection of β cells from
lipoapoptosis, we treated prediabetic Zucker Diabetic Fatty rats with 200 ... Cited by 181 - Related articles - BL Direct - All 7 versions
