I Rooman, J Lardon, L Bouwens - Diabetes, 2002 - Am Diabetes Assoc It is still unclear which factors regulate pancreatic regeneration and β-cell
neogenesis and which precursor cells are involved. We evaluated the role of
intravenously infused gastrin in regenerating pancreas of duct-ligated ... Cited by 103 - Related articles - BL Direct - All 4 versions
I Rooman, J Lardon, D Flamez, F Schuit, L … - Gastroenterology, 2001 - Elsevier Ductular metaplastic cells are observed during pancreas injury. Growth control
by gastrin and expression of gastrin/cholecystokinin (CCK) B receptors were
evaluated in these cells. Acinoductal transdifferentiation was induced in ... Cited by 56 - Related articles - BL Direct - All 10 versions
I Rooman, L Bouwens - Diabetologia, 2004 - Springer Aims/hypothesis. Increasing beta-cell mass and/or function could restore glucose
homeostasis in diabetes mellitus. Hitherto, trophic factors for beta-cell regen-
eration after toxic events have been difficult to identi- fy. We evaluated ... Cited by 64 - Related articles - BL Direct - All 4 versions
I Rooman, Y Heremans, H Heimberg, L … - Diabetologia, 2000 - Springer Aims/hypothesis. In adult pancreatic regeneration models exocrine acini are
found to transdifferentiate to duct-like complexes. This has also been
associated with the formation of new endocrine islet cells. We aimed to ... Cited by 121 - Related articles - BL Direct - All 3 versions
SJ Brand, S Tagerud, P Lambert, SG Magil, K … - Pharmacology and Toxicology, 2002 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 51 - Related articles - BL Direct - All 4 versions
J Lardon, N Huyens, I Rooman, L Bouwens - Virchows Archiv, 2004 - Springer Abstract Injured pancreatic tissue, for example, after duct ligation, undergoes
remodeling, which involves the replacement of exocrine acini by duct-like
structures. This acinoductal metaplasia is probably at least partly due to ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►endojournals.org WL Suarez-Pinzon, JRT Lakey, SJ Brand, A … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Pancreatic islet transplantation is a viable treatment for type 1 diabetes, but
is limited by human donor tissue availability. The combination of epidermal
growth factor (EGF) and gastrin induces islet ß-cell neogenesis from ... Cited by 69 - Related articles - All 5 versions
RN Wang, JF Rehfeld, FC Nielsen, G Klöppel - Diabetologia, 1997 - Springer A better understanding of the mechanisms that regu- late beta cell growth and
regeneration might be use- ful in the treatment of diabetes mellitus, the hope
be- ing that diabetes could be treated by either stimulat- ing the growth ... Cited by 64 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org M Lipsett, DT Finegood - Diabetes, 2002 - Am Diabetes Assoc Over the past few decades, we have come to appreciate that the β-cell mass is
dynamic, with a significant capacity for adaptation to changes in insulin demand
(1). Increases in β-cell mass may occur through increased β-cell ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] TC Wang, S Bonner-Weir, PS Oates, M Chulak … - Journal of Clinical Investigation, 1993 - pubmedcentral.nih.gov Gastrin is transiently expressed in fetal islets during a critical period of
their development from protodifferentiated islet pre- cursors in fetal
pancreatic ducts. To examine the possible role of gastrin as an islet cell ... Cited by 142 - Related articles - BL Direct - All 9 versions
