MC Lawrence, HS Bhatt, RA Easom - Diabetes, 2002 - Am Diabetes Assoc Currently there is intense interest to define the mechanism of action of
glucagon-like peptide-1 (GLP-1) in regulating β-cell function, including
insulin gene transcription. In this study, GLP-1 (100 nmol/l), in the ... Cited by 46 - Related articles - BL Direct - All 5 versions
- ►endojournals.org MC Lawrence, HS Bhatt, JM Watterson, RA … - Molecular Endocrinology, 2001 - Endocrine Soc Immunosuppressants such as FK506 (tacrolimus), the primary cellular target of
which is calcineurin, decrease ß-cell insulin content and preproinsulin mRNA
expression. This study offers an explanation for this effect by ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►jbc.org MC Lawrence, K McGlynn, BH Park, MH Cobb - Journal of Biological Chemistry, 2005 - ASBMB The insulin promoter is both positively and negatively regulated in response to
conditions to which pancreatic -cells are exposed. Exposure of intact rat islets
and INS-1 pancreatic -cells to 11 mM glucose for minutes to hours results ... Cited by 35 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] G Skoglund, MA Hussain, GG Holz - Diabetes, 2000 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1), a hormonal activator of adenyl cyclase,
stimulates insulin gene transcription, an effect mediated by the cAMP response
element (CRE) of the rat insulin I gene promoter (RIP1). Here we demon- ... Cited by 70 - Related articles - BL Direct - All 15 versions
- ►endojournals.org DM Kemp, JF Habener - Endocrinology, 2001 - Endocrine Soc The insulin gene promoter contains many transcriptional response elements that
predispose the gene to a wide range of regulatory signals. Glucagon-like peptide
1 (GLP-1) stimulates insulin gene transcription by intracellular second ... Cited by 24 - Related articles - BL Direct - All 2 versions
- ►endojournals.org LB Lester, MC Faux, JB Nauert, JD Scott - Endocrinology, 2001 - Endocrine Soc Protein kinases and phosphatases play key roles in integrating signals from
various insulin secretagogues. In this study, we show that the activities of the
cAMP-dependent protein kinase (PKA) and the calcium/calmodulin-dependent ... Cited by 52 - Related articles - BL Direct - All 4 versions
JJ Heit, ÅA Apelqvist, X Gu, MM Winslow, JR … - Nature, 2006 - nature.com The growth and function of organs such as pancreatic islets adapt to meet
physiological challenges and maintain metabolic balance, but the mechanisms
controlling these facultative responses are unclear 1, 2 . Diabetes in ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►endojournals.org OG Chepurny, MA Hussain, GG Holz - Endocrinology, 2002 - Endocrine Soc Signal transduction properties of exendin-4 (Ex-4) underlying its ability to
stimulate rat insulin I gene promoter (RIP1) activity were assessed in the
pancreatic ß-cell line INS-1. Ex-4 acted via glucagon-like peptide-1 ... Cited by 31 - Related articles - BL Direct - All 12 versions
- ►pnas.org [PDF] N Inagaki, T Maekawa, T Sudo, S Ishii, Y … - Proceedings of the National Academy of Sciences, 1992 - National Acad Sciences ABSTRACT Glucose is known to increase the cAMP con- centration in pancreatic (
cells. To determine the mechanism by which cAMP augments insulin gene
expression, we first identified the cAMP response elements (CREs) of the ... Cited by 64 - Related articles - All 9 versions
- ►endojournals.org X Wang, J Zhou, ME Doyle, JM Egan - Endocrinology, 2001 - Endocrine Soc Glucagon-like peptide-1 (GLP-1) enhances insulin secretion and synthesis. It
also regulates the insulin, glucokinase, and GLUT2 genes. It mediates increases
in glucose-stimulated insulin secretion by activating adenylyl cyclase and ... Cited by 71 - Related articles - BL Direct - All 3 versions
