- ►diabetesjournals.org C Mur, AM Valverde, CR Kahn, M Benito - Diabetes, 2002 - Am Diabetes Assoc Immortalized brown adipocyte cell lines have been generated from fetuses of mice deficient in
the insulin-like growth factor I receptor gene (IGF-IR −/− ), as well as from fetuses of wild-type
mice (IGF-IR +/+ ). These cell lines maintained the expression of adipogenic- and ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►aacrjournals.org H Zhang, AM Pelzer, DT Kiang, D Yee - Cancer Research, 2007 - AACR Multiple lines of evidence have indicated a critical role of the type I insulin-like growth factor
(IGF) receptor (IGF1R) in many types of cancer, including breast, prostate, colon, and melanoma
(1). This receptor is composed of extracellular subunits covalently linked to the ß subunits, ... Cited by 27 - Related articles - BL Direct - All 3 versions
- ►endojournals.org C Mur, M Arribas, M Benito, AM Valverde - Endocrinology, 2003 - Endocrine Soc To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and thermogenic differentiation
of brown adipocytes during late fetal life, we have established immortalized brown adipocyte
cell lines from fetuses of IGF-IR-deficient mice (IGF-IR -/- ) as well as from wild-type mice ( ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►jbc.org K Fulzele, DJ DiGirolamo, Z Liu, J Xu, JL Messina, … - Journal of Biological …, 2007 - ASBMB Defective bone formation is common in patients with diabetes, suggesting that insulin normally
exerts anabolic actions in bone. However, because insulin can cross-activate the insulin-like
growth factor type 1 receptor (IGF-1R), which also functions in bone, it has been difficult to ... Cited by 15 - Related articles - All 4 versions
[CITATION] Y895IRS-1/GRB-2 association mediates the insulin signaling involved in IRS-1- …
AM Valverde, C Mur, S Pons, A Alvarez, MF White, CR … - Mol Cell Biol, 2001 Cited by 2 - Related articles
[CITATION] cAMP inhibits IGF-I-induced proliferation in fetal rat brown adipocytes
S Urs, A Harrington, L Liaw, D Small - Transgenic research, 2006 - Springer Abstract Mouse strains expressing the site-spe- cific Cre recombinase facilitate conditional
abla- tion or activation of genomic sequences when one or several exons of a gene of interest
are flanked by loxP sites. Recently, several strains targeting Cre expression to adipocytes ... Cited by 4 - Related articles - BL Direct - All 5 versions
Y Zou, WB Tsai, CJ Cheng, C Hsu, Y … - Breast Cancer …, 2008 - breast-cancer-research.com Estrogen receptors (ERs) play key roles in breast cancer development and influence treatment
outcome in breast cancer patients. Identification of molecules that regulate ER function may facilitate
development of breast cancer treatment strategies. The forkhead box class O (FOXO) ... Cited by 6 - Related articles - Cached - All 6 versions
C Blanquart, J Achi, T Issad - Biochemical Pharmacology, 2008 - Elsevier The insulin receptor (IR) is composed of two α-chains that bind ligands and two β-chains that
possess an intracellular tyrosine kinase activity. The IR is expressed in cells as two isoforms
containing or not exon 11 (IRB and IRA, respectively). Several mRNA studies have ... Cited by 5 - Related articles - All 3 versions
- ►nih.gov AM Valverde, C Mur, S Pons, AM Alvarez, MF … - Molecular and Cellular …, 2001 - Am Soc Microbiol We have recently generated immortalized fetal brown adipocyte cell lines from insulin receptor
substrate 1 (IRS-1) knockout mice and demonstrated an impairment in insulin-induced lipid synthesis
as compared to wild-type cell lines. In this study, we investigated the consequences of ... Cited by 16 - Related articles - BL Direct - All 7 versions
