MK Dea, M Hamilton-Wessler, M Ader, D Moore, L … - Diabetes, 2002 - Am Diabetes Assoc NN304 [Lys B29 -tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog
designed to exhibit protracted glucose-lowering action. In dogs with infusion rates similar to insulin
itself, NN304 exhibits similar glucose uptake (R d ) stimulation with delayed onset of ... Cited by 35 - Related articles - BL Direct - All 5 versions
M Hamilton-Wessler, M Ader, M Dea, D Moore, PN … - Diabetologia, 1999 - Springer Over the last decade, extensive effort has been dedi- cated to the development of soluble human
insulin analogues with a more prolonged and reproducible ... Mechanism of protracted metabolic
effects of fatty acid acylated ... M. Hamilton-Wessler 1 , M. Ader 1 , M. Dea 1 , D. Moore 1 , ... Cited by 46 - Related articles - BL Direct - All 3 versions
M Hamilton-Wessler, M Ader, MK Dea, D Moore, M … - Diabetes, 2002 - Am Diabetes Assoc A defect in transcapillary transport of insulin in skeletal muscle and adipose tissue has been
proposed to play a role in the insulin resistance that leads to type 2 diabetes, yet the mechanism
of insulin transfer across the capillary endothelium from plasma to interstitium continues ... Cited by 26 - Related articles - BL Direct - All 4 versions
GA Brunner, G Sendlhofer, A Wutte, M … - Experimental and …, 2000 - thieme-connect.com NN304 is a long-acting insulin analogue that is acylated with a 14-C-fatty acid chain. Protraction
of action of this novel insulin analogue is due not to slow absorption after subcutaneous administration
but to reversible binding to albumin. We investigated the pharmacokinetic and ... Cited by 62 - Related articles - BL Direct - All 6 versions
JL Whittingham, S Havelund, I Jonassens - Biochemistry, 1997 - pubs.acs.org The fatty acid acylated insulin, Lys B29 -tetradecanoyl, des-(B30) human insulin, has been crystallized
and the structure determined by X-ray crystallography. The fatty acid substituent on residue B29
Lys binds reversibly to circulating albumin protein in vivo, and by this mechanism the ... Cited by 45 - Related articles - BL Direct - All 5 versions
[CITATION] Pharmacokinetics of insulin detemir in subjects with renal or hepatic impairment
P Kurtzhals, S Havelund, I Jonassen, J … - Journal of …, 1997 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 56 - Related articles - BL Direct - All 4 versions
[CITATION] Soluble, prolonged-acting insulin derivatives. I. Degree of protraction and …
P Kurtzhals, U Ribel - Diabetes, 1995 - Am Diabetes Assoc The Co(3+)-insulin hexamer is an extraordinary stable insulin hexamer that has no affinity for
the insulin receptor per se but is converted into active insulin in vivo. In the present study, we
evaluated the action profile of Co(3+)-insulin after subcutaneous injection into ... Cited by 14 - Related articles - BL Direct - All 5 versions
