- ►diabetesjournals.org M Kishi, J Tanabe, JD Schmelzer, PA Low - Diabetes, 2002 - Am Diabetes Assoc Chronic hyperglycemia results in a predominantly sensory neuropathy. Recent studies suggest
that dorsal root ganglion (DRG) neurons comprise a specific target and may be responsible for
the important complication of diabetic sensory neuropathy, since hyperglycemia for ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org DW Zochodne, VMK Verge, C Cheng, H Sun, J … - Brain, 2001 - Oxford Univ Press Targeting of dorsal root ganglia by diabetes could account for the selective sensory abnormalities
that patients with early diabetic polyneuropathy develop. In this work, we addressed survival,
phenotype and gene expression in sensory neurones in lumbar dorsal root ganglia in a ... Cited by 56 - Related articles - BL Direct - All 5 versions
NM Sayers, LJ Beswick, A Middlemas, NA Calcutt, AP … - Diabetes, 2003 - Am Diabetes Assoc The relation between neurofilament expression and/or phosphorylation in the proximal versus
distal components of the sensory peripheral neuraxis was studied and related to disorders in
structure and function of the distal axon of streptozocin (STZ)-induced diabetic rats ... Cited by 30 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org TJ Huang, SA Price, L Chilton, NA Calcutt, DR … - Diabetes, 2003 - Am Diabetes Assoc Mitochondrial dysfunction has been proposed as a mediator of neurodegeneration in diabetes
complications. The aim of this study was to determine whether deficits in insulin-dependent neurotrophic
support contributed to depolarization of the mitochondrial membrane in sensory neurons ... Cited by 56 - Related articles - BL Direct - All 5 versions
JW Russell, KA Sullivan, AJ Windebank, DN … - Neurobiology of disease, 1999 - Elsevier Recent clinical trials indicate that the severity of diabetic neuropathy is correlated with the level
of patient glycemic control. In the current study, hyperglycemia induces apoptotic changes in
dorsal root ganglion neurons and Schwann cells in vivo both in streptozotocin-treated ... Cited by 178 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org C Cheng, DW Zochodne - Diabetes, 2003 - Am Diabetes Assoc Long-term experimental diabetes may best model the prominent and irreversible sensory deficits
of chronic human diabetic polyneuropathy. Whereas irretrievable loss of sensory neurons, if
present, would be an unfortunate feature of the disease, systematic unbiased counting ... Cited by 79 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AM Schmeichel, JD Schmelzer, PA Low - Diabetes, 2003 - Am Diabetes Assoc We evaluated the effects of chronic hyperglycemia on L5 dorsal root ganglion (DRG) neurons
using immunohistochemical and electrophysiologic techniques for evidence of oxidative
injury. Experimental diabetic neuropathy was induced by streptozotocin. To evaluate the ... Cited by 147 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org [PDF] S Srinivasan, M Stevens, JW Wiley - Diabetes, 2000 - Am Diabetes Assoc We hypothesized that diabetic sensory neuropathy is associated with activation of apoptosis
and concomitant mitochondrial dysfunction. Studies were performed in excised intact and acutely
dissociated dorsal root gan- glion (DRG) neurons from control and streptozotocin- ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org JN Scott, AW Clark, DW Zochodne - Brain, 1999 - Oxford Univ Press In human and experimental diabetes, the relationship between molecular abnormalities in perikarya
of sensory neurons and structural abnormalities in their distal axons is largely unexplored. In
this study we examined neurofilament (Nf) and tubulin messenger RNA (mRNA) ... Cited by 64 - Related articles - BL Direct - All 4 versions
AP Mizisin, NA Calcutt, DR Tomlinson, A … - Journal of the …, 1999 - ncbi.nlm.nih.gov The ability of neurotrophin-3 (NT-3) to reverse established nerve disorders was investigated
in the peripheral neuraxis of streptozotocin-diabetic rats. Sciatic sensory and motor nerve conduction
velocity deficits established after 2 months of diabetes were completely normalized by ... Cited by 34 - Related articles - BL Direct - All 2 versions
