- ►diabetesjournals.org PC Reifsnyder, EH Leiter - Diabetes, 2002 - Am Diabetes Assoc Obesity-driven type 2 diabetes (diabesity) involves complex genetic and environmental interactions
to trigger disease. Here, we combine variable numbers of known quantitative trait loci (QTL) for
obesity and diabetes contributed by New Zealand Obese (NZO/HlLt) and Nonobese ... Cited by 41 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org EH Leiter, PC Reifsnyder - Diabetes, 2004 - Am Diabetes Assoc The genetic basis for the more common forms of human obesity predisposing to insulin resistance
and development of type 2 diabetes is multigenic rather than monogenic in origin. New mouse
“diabesity” models have been created by combining independent diabetes risk-conferring ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] EH Leiter, PC Reifsnyder, K Flurkey, HJ Partke, E … - Diabetes, 1998 - Am Diabetes Assoc We used mouse genetics to model how polygenic thresh- olds for the transition from impaired
glucose tolerance (IGT) to NIDDM are reached. NON/Lt and NZO/Hl are inbred mouse strains
selected for IGT and polygenic obe- sity, respectively. Their F1 male progeny consistently ... Cited by 68 - Related articles - BL Direct - All 4 versions
E Junger, L Herberg, K Jeruschke, EH Leiter - Laboratory Investigation, 2002 - nature.com We report the first combined light and electron microscopic analysis of the pancreas during the
development of type 2 diabetes in the New Zealand Obese (NZO) mouse. As in most other polygenic
rodent models of type 2 diabetes, hyperglycemia associated with beta cell destruction is ... Cited by 14 - Related articles - BL Direct - All 3 versions
RA Koza, K Flurkey, DM Graunke, C Braun, HJ Pan, PC … - Metabolism, 2004 - Elsevier New Zealand Obese (NZO) male mice develop a polygenic juvenile-onset obesity and
maturity-onset hyperinsulinemia and hyperglycemia (diabesity). Here we report on metabolic
and molecular changes associated with the antidiabesity action of CL316,243 (CL), a β 3 - ... Cited by 14 - Related articles - All 12 versions
- ►diabetesjournals.org [PDF] L Plum, R Kluge, K Giesen, J Altmuller, JR Ortlepp, HG … - Diabetes, 2000 - Am Diabetes Assoc A backcross model of New Zealand obese mice (NZO) with the lean, atherosclerosis-resistant
SJL strain was established to locate genes responsible for obesity, insulin resistance, and type
2 diabetes–like hypergly- cemia. In male NZO F1 backcross mice, a major sus- ceptibility ... Cited by 24 - Related articles - BL Direct - All 4 versions
JR Ortlepp, R Kluge, K Giesen, L Plum, P … - European journal of …, 2000 - pt.wkhealth.com Institut für Pharmakologie und Toxikologie (JR Ortlepp, K. Giesen, L. Plum, H.-G. Joost), Medizinische
Klinik I (JR Ortlepp, P. Radke, P. Hanrath) and Institut für Versuchstierkunde (R. Kluge), Medizinische
Fakultät der RWTH Aachen, Pauwelsstrae 30, D-52057 Aachen, Germany. Cited by 40 - Related articles - BL Direct - All 5 versions
L Plum, K Giesen, R Kluge, E Junger, K Linnartz, A … - Diabetologia, 2002 - Springer Aims/hypothesis. The diabetes susceptibility locus Nidd/SJL was identified in an outcross of New
Zealand obese (NZO) and lean Swiss/Jackson Laboratory mouse strain (SJL) mice. Here we
characterise its effects in a NZO × F1(SJL×NZO) backcross population raised on high-fat ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►171.66.122.45 PC Reifsnyder, G Churchill, EH Leiter - Genome Research, 2000 - 171.66.122.45 Obesity, a major risk factor for type II diabetes, is becoming more prevalent in Western populations
consuming high calorie diets while expending less energy both at the workplace and at
home. Most human obesity, and probably most type II diabetes as well, reflects polygenic ... Cited by 99 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org HJ Pan, P Reifsnyder, DE Vance, Q Xiao, EH Leiter - Diabetes, 2005 - Am Diabetes Assoc Although thiazolidinediones suppress hyperglycemia in diabetic (NON × NZO)F1 males, these
mice exhibit unusual sensitivity to drug-induced exacerbation of an underlying hepatosteatosis
only rarely experienced in human patients. To establish the pharmacogenetic basis for ... Cited by 13 - Related articles - All 7 versions
