LM t Hart, G Nijpels, JM Dekker, J Maassen, … - Diabetes, 2002 - Am Diabetes Assoc Associations between type 2 diabetes (and/or parameters contributing to glucose
homeostasis) and genetic variation in the genes encoding insulin receptor
substrate (IRS)-1 and -2 have been reported in several populations. ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►uu.nl [PDF] M Leen, G Nijpels, JM Dekker, JA Maassen, … - Age (years) - Am Diabetes Assoc Associations between type 2 diabetes (and/or parame- ters contributing to
glucose homeostasis) and genetic variation in the genes encoding insulin
receptor sub- strate (IRS)-1 and -2 have been reported in several ... Related articles - All 2 versions
- ►diabetesjournals.org S Le Fur, C Le Stunff, P Bougnères - Diabetes, 2002 - Am Diabetes Assoc In two cohorts of 174 and 165 obese Caucasian children, we measured insulin
sensitivity and genotyped insulin receptor substrate IRS-1 and IRS-2 genes for
the Arg972Gly and the Asp1057Gly variants, respectively. Because IRS-1 and ... Cited by 9 - Related articles - BL Direct - All 4 versions
D Berger, I Barroso, M Soos, G Yeo, AJ … - Diabetic Medicine, 2002 - interscience.wiley.com MethodsThe IRS-1 gene was scanned for mutations in 83 unrelated affected
subjects and 47 unaffected individuals using fluorescent single-strand
conformation polymorphism (fSSCP) analysis. A novel heterozygous mutation, ... Cited by 10 - Related articles - BL Direct - All 4 versions
S Mammarella, B Creati, DL Esposito, P Arcuri … - Human mutation, 1998 - ncbi.nlm.nih.gov We analyzed by SSCP the complete IRS-1 coding sequence in NIDDM patient #25 D.
Unique conformers corresponding to a Ser to Tyr substitution at codon 1043
(S1043Y), and to a Cys to Tyr substitution at codon 1095 (C1095Y) were ... Cited by 3 - Related articles
- ►endojournals.org A Fritsche, A Madaus, W Renn, O Tschritter, A … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Disruption of the insulin receptor substrate-2 was shown to cause type 2
diabetes in mice. This could be largely attributed to abnormal ß-cell
development. In humans, a prevalent polymorphism in insulin receptor ... Cited by 14 - Related articles - BL Direct - All 5 versions
JB Ruige, JM Dekker, G Nijpels, C Popp- … - Diabetologia, 1999 - Springer Summary In subjects with impaired glucose toler- ance hyperproinsulinaemia has
been shown to be pre- dictive for progression to Type II (non-insulin-depen-
dent) diabetes mellitus. These findings are often in- terpreted as early ... Cited by 25 - Related articles - BL Direct - All 5 versions
MF Shehata - Cardiovascular diabetology, 2008 - cardiab.com Despite the marked advances in research on insulin resistance (IR) in humans and
animal models of insulin resistance, the mechanisms underlying high salt-induced
insulin resistance remain unclear. Insulin resistance is a multifactorial ... Cited by 5 - Related articles - Cached - All 8 versions
M Stumvoll, A Fritsche, A Volk, N Stefan, A … - Diabetes, 2001 - Am Diabetes Assoc The Gly972Arg polymorphism in the insulin receptor substrate (IRS)-1 was found
in some studies to have a higher prevalence in type 2 diabetic subjects than in
control subjects. Previously, transfection of IRS-1 with this polymorphism ... Cited by 58 - Related articles - BL Direct - All 4 versions
MF Shehata - Cardiovascular diabetology, 2008 - cardiab.com Insulin resistance has been extensively investigated during the past decade
because of its proposed role in initiating a cluster of cardiovascular risk
factors including hypertension. Insulin resistance is an inherited genetic ... Cited by 7 - Related articles - Cached - All 7 versions
