- ►diabetesjournals.org I Gabriely, XH Ma, XM Yang, L Rossetti, N … - Diabetes, 2002 - Am Diabetes Assoc Increased fat mass, abdominal adiposity, and insulin resistance are typical
findings in aging mammals and are frequently associated with leptin resistance
and increased plasma leptin levels. To examine whether leptin's failure in ... Cited by 54 - Related articles - BL Direct - All 5 versions
XH Ma, R Muzumdar, XM Yang, I Gabriely, R … - Journals of Gerontology Series A: Biological and …, 2002 - Geron Soc America Leptin has been shown to modulate total body fat and visceral fat distribution
and to enhance insulin action in young rats. We hypothesize that failure of
leptin action may contribute to the increase in visceral fat and insulin ... Cited by 28 - Related articles - BL Direct - All 3 versions
X Ma, R Muzumdar, I Gabriely, G Atzmon, N … - Clinical Neuroscience Research, 2003 - Elsevier We hypothesize that age-related metabolic alterations originate in the brain
(studies in rodents), and that the functional decline of the brain may be
protected by a favorable metabolic profile (studies in human centenarians). ... Related articles - All 7 versions
M Sánchez-Rodrı́guez, A Garcı́a-Sánchez … - Archives of Medical Research, 2000 - Elsevier Leptin is a protein produced by adipocytes that reduces reflex appetite by
blocking the Y neuropeptide, thus causing body weight loss. A large percentage
of elderly people are reported to exhibit obesity, which may be caused by ... Cited by 12 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org [PDF] PJ Scarpace, M Matheny, RL Moore, N Tümer - Diabetes, 2000 - Am Diabetes Assoc We previously reported that adiposity and serum leptin levels increase with age
in male F-344 BN rats and that when physiological levels of serum leptin are
manipulated by fasting, there is a corresponding recip- rocal change in ... Cited by 70 - Related articles - BL Direct - All 3 versions
H Li, M Matheny, M Nicolson, N Tümer, PJ … - Diabetes, 1997 - Am Diabetes Assoc Humans and rats tend to gain weight as they age. Leptin is one regulator of food
intake and energy expenditure. To determine if the increase in adiposity with
age is related to altered leptin gene expression, we assessed adiposity ... Cited by 82 - Related articles - BL Direct - All 4 versions
PJ Scarpace, M Matheny, EW Shek - Neuropharmacology, 2000 - Elsevier Leptin contributes to the regulation of both food intake and energy expenditure.
We previously demonstrated that the F-344×BN rat, a rodent model for late-onset
obesity, is leptin resistant, suggesting that leptin signal transduction ... Cited by 50 - Related articles - BL Direct - All 4 versions
PJ Scarpace, N TÜMER - Physiology & behavior, 2001 - cat.inist.fr Leptin contributes to the regulation of both food intake and energy expenditure.
Serum leptin is elevated in most obese humans, and that obesity persists in
spite of the elevated leptin, suggesting leptin resistance. The F-344 x BN ... Cited by 40 - Related articles - BL Direct - All 3 versions
- ►fasebj.org ZWEI WANG, WENT PAN, Y LEE, T KAKUMA … - The FASEB Journal, 2001 - FASEB Leptin resistance has been implicated in the pathogenesis of obesity-related
complications involving abnormalities of lipid metabolism that resemble those of
old age. To determine whether development of leptin resistance in advancing ... Cited by 95 - Related articles - BL Direct - All 2 versions
- ►physiology.org H Li, M Matheny, N Tumer, PJ Scarpace - American Journal of Physiology- Endocrinology And …, 1998 - Am Physiological Soc To investigate the role of aging on the fasting-induced suppression of leptin
gene expression and increase in hypothalamic neuropeptide Y (NPY) gene
expression, we fasted or fed ad libitum male F-344xBN rats aged 3, 24, and ... Cited by 52 - Related articles - BL Direct - All 5 versions
