- ►diabetesjournals.org T Albrektsen, KS Frederiksen, WE Holmes, E Boel, K … - Diabetes, 2002 - Am Diabetes Assoc Thiazolidinediones (TZDs) are a new class of compounds that improve insulin sensitivity in type
2 diabetic patients as well as in rodent models of this disease. These compounds act as ligands
for a member of the nuclear hormone receptor superfamily, peroxisome proliferator– ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►endojournals.org DL Gerhold, F Liu, G Jiang, Z Li, J Xu, M Lu, JR Sachs, … - Endocrinology, 2002 - Endocrine Soc PPAR is an adipocyte-specific nuclear hormone receptor. Agonists of PPAR , such as thiazolidinediones
(TZDs), promote adipocyte differentiation and have insulin-sensitizing effects in animals and
diabetic patients. Affymetrix oligonucleotide arrays representing 6347 genes were ... Cited by 101 - Related articles - BL Direct - All 3 versions
BE Gould Rothberg, SS Sundseth, VA DiPippo, PJ … - Functional & Integrative …, 2001 - Springer Abstract Expression pharmacogenomics includes differ- ential gene expression (DGE) profiling
of drug responses in model systems to generate a set of differentially modu- lated drug-responsive
genes which can serve as a surro- gate measure for drug action. In this manner, ... Cited by 16 - Related articles - All 4 versions
A Suzuki, T Yasuno, H Kojo, J Hirosumi, S Mutoh, Y … - The Japanese Journal of …, 2000 - J-STAGE Jpn. J. Pharmacol. 84, 113-123 (2000) Alteration in Expression Profiles of a Series of
Diabetes-Related Genes in db/db Mice Following Treatment With Thiazolidinediones Akiko
Suzuki, Tora Yasuno, Hitoshi Kojo*, Jiro Hirosumi, Seitaro Mutoh and Yoshitada Notsu ... Cited by 21 - Related articles - BL Direct - All 3 versions
- ►endojournals.org Y Li, MA Lazar - Molecular Endocrinology, 2002 - Endocrine Soc The PPAR is a key adipogenic determination factor. Ligands for PPAR such as antidiabetic thiazolidinedione
(TZD) compounds are adipogenic, and many adipocyte genes that are activated by TZDs contain
binding sites for PPAR . Like ligands for other nuclear receptors, TZDs can regulate ... Cited by 69 - Related articles - BL Direct - All 5 versions
H Koutnikova, J Auwerx - ANNALS-NEW YORK ACADEMY OF …, 2002 - interscience.wiley.com Abstract: Evidence from both human genetic studies and characterization of peroxisome
proliferator-activated receptor gamma (PPARγ) knockout mice suggested that the prime function
of PPARγ is fat formation and that its role in insulin sensitization might be secondary to ... Cited by 4 - Related articles - BL Direct - All 3 versions
DG Carey, GJ Cowin, GJ Galloway, NP Jones, JC … - Obesity research, 2002 - cat.inist.fr Objective: To investigate the effects of rosiglitazone(RSG) on insulin sensitivity and regional
adiposity(including intrahepatic fat) in patients with type 2 diabetes. Research Methods and
Procedures: We examined the effect of RSG(8 mg/day, 2 divided doses) compared with ... Cited by 20 - Related articles - BL Direct
- ►aspetjournals.org T Albrektsen, J Fleckner - Molecular Pharmacology, 2001 - ASPET Thiazolidinediones (TZDs) are a new class of compounds that improve the insulin sensitivity
in patients with non-insulin-dependent diabetes mellitus (NIDDM) as well as in rodent models
of NIDDM. These compounds act as high-affinity ligands for a member of the nuclear ... Cited by 6 - Related articles - BL Direct - All 3 versions
- ►endojournals.org J Rieusset, F Touri, L Michalik, P Escher, B … - Molecular …, 2002 - Endocrine Soc Peroxisome proliferator-activated receptor (PPAR- ) plays a key role in adipocyte differentiation
and insulin sensitivity. Its synthetic ligands, the thiazolidinediones (TZD), are used as insulin
sensitizers in the treatment of type 2 diabetes. These compounds induce both adipocyte ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►endojournals.org HS Camp, A Chaudhry, T Leff - Endocrinology, 2001 - Endocrine Soc The antidiabetic thiazolidinediones, which include troglitazone and rosiglitazone, are ligands
for the nuclear receptor peroxisome proliferator-activated receptor (PPAR ). Their antihyperglycemic
effects seem to be linked to the regulation of PPAR -responsive genes. Here, we report ... Cited by 68 - Related articles - BL Direct - All 2 versions
