- ►diabetesjournals.org P Vollenweider, B Ménard, P Nicod - Diabetes, 2002 - Am Diabetes Assoc Impaired glucose tolerance (IGT) is characterized by insulin resistance. Recently, defects in the
insulin-signaling cascade have been implicated in the pathogenesis of insulin resistance. To
study insulin signaling in IGT, we used human skeletal muscle cells in primary culture ... Cited by 88 - Related articles - BL Direct - All 5 versions
M Beeson, MP Sajan, M Dizon, D Grebenev, J Gomez- … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance in type 2 diabetes is partly due to impaired glucose transport in skeletal
muscle. Atypical protein kinase C (aPKC) and protein kinase B (PKB), operating downstream
of phosphatidylinositol (PI) 3-kinase and its lipid product, PI-3,4,5-(PO 4 ) 3 (PIP 3 ), ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►endojournals.org G Bandyopadhyay, Y Kanoh, MP Sajan, ML Standaert, … - Endocrinology, 2000 - Endocrine Soc We used adenoviral gene transfer methods to evaluate the role of atypical protein kinase Cs
(PKCs) during insulin stimulation of glucose transport in L6 myotubes. Expression of wild-type
PKC- potentiated maximal and half-maximal effects of insulin on 2-deoxyglucose uptake, ... Cited by 79 - Related articles - BL Direct - All 2 versions
YB Kim, K Kotani, TP Ciaraldi, RR Henry, BB Kahn - Diabetes, 2003 - Am Diabetes Assoc In humans with obesity or type 2 diabetes, insulin target tissues are resistant to many actions
of insulin. The atypical protein kinase C (PKC) isoforms λ and ζ are downstream of
phosphatidylinositol-3 kinase (PI3K) and are required for maximal insulin stimulation of ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Y Kanoh, MP Sajan, G Bandyopadhyay, A Miura, ML … - Endocrinology, 2003 - Endocrine Soc Insulin-stimulated glucose transport in skeletal muscle is thought to be effected at least partly
through atypical protein kinase C isoforms (aPKCs) operating downstream of phosphatidylinositol
(PI) 3-kinase and 3-phosphoinositide-dependent protein kinase-1 (PDK-1). However, ... Cited by 30 - Related articles - BL Direct - All 3 versions
- ►endojournals.org Y Kanoh, G Bandyopadhyay, MP Sajan, ML Standaert, … - Endocrinology, 2001 - Endocrine Soc Atypical protein kinases C (PKCs), and , and protein kinase B (PKB) are thought to function downstream
of phosphatidylinositol 3-kinase (PI 3-kinase) and regulate glucose transport during insulin action
in skeletal muscle and adipocytes. Insulin-stimulated glucose transport is defective in type ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►endojournals.org G Bandyopadhyay, MP Sajan, Y Kanoh, ML … - Journal of Clinical …, 2002 - Endocrine Soc Insulin-stimulated glucose transport is impaired in the early phases of type 2 diabetes
mellitus. Studies in rodent cells suggest that atypical PKC (aPKC) isoforms ( , , and ) and
PKB, and their upstream activators, PI3K and 3-phosphoinositide-dependent protein ... Cited by 45 - Related articles - BL Direct - All 4 versions
- ►nih.gov YB Kim, SE Nikoulina, TP Ciaraldi, RR … - Journal of Clinical …, 1999 - Am Soc Clin Investig To determine whether the serine/threonine kinase Akt (also known as protein kinase B) is activated
in vivo by insulin administration in humans, and whether impaired activation of Akt could play
a role in insulin resistance, we measured the activity and phosphorylation of Akt isoforms ... Cited by 262 - Related articles - BL Direct - All 10 versions
GJ Etgen, KM Valasek, CL Broderick, AR Miller - Journal of Biological Chemistry, 1999 - ASBMB An in vivo adenoviral gene delivery system was utilized to assess the effect of overexpressing
protein kinase C (PKC)-ζ on rat skeletal muscle glucose transport activity. Female lean Zucker
rats were injected with adenoviral/human PKC-ζ (hPKC-ζ) and adenoviral/LacZ in ... Cited by 61 - Related articles - All 5 versions
ML Standaert, HK Ortmeyer, MP Sajan, Y Kanoh, G … - Diabetes, 2002 - Am Diabetes Assoc Rhesus monkeys frequently develop obesity and insulin resistance followed by type 2 diabetes
when allowed free access to chow. This insulin resistance is partly due to defective glucose transport
into skeletal muscle. In this study, we examined signaling factors required for insulin- ... Cited by 35 - Related articles - BL Direct - All 4 versions
