CB Whorwood, SJ Donovan, D Flanagan, DIW … - Diabetes, 2002 - Am Diabetes Assoc Altered glucocorticoid hormone action may contribute to the etiology of the
metabolic syndrome, but the molecular mechanisms are poorly defined. Tissue
sensitivity to glucocorticoid is regulated by expression of the ... Cited by 103 - Related articles - BL Direct - All 5 versions
RM Reynolds, KE Chapman, JR Seckl, BR … - Jama, 2002 - Am Med Assoc We obtained biopsies of vastus lateralis skeletal muscle under local anesthesia
from 23 men without fasting hyperglycemia participating in the the Uppsala
Longitudinal Study of Adult Men. 3 As previously described, participants ... Cited by 36 - Related articles - All 3 versions
- ►endojournals.org O Paulmyer-Lacroix, S Boullu, C Oliver, MC … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Glucocorticoids play an important role in determining adipose tissue metabolism
and distribution. Patients with Cushing's syndrome or receiving corticosteroid
therapy develop a reversible visceral obesity. In obese patients, although ... Cited by 156 - Related articles - BL Direct - All 4 versions
- ►endojournals.org IJ Bujalska, EA Walker, M Hewison, PM … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc As exemplified in patients with Cushing's syndrome, glucocorticoids play an
important role in regulating adipose tissue distribution and function, but
circulating cortisol concentrations are normal in most patients with ... Cited by 89 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JW Tomlinson, B Sinha, I Bujalska, M … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Central obesity is associated with increased morbidity and mortality.
Preadipocyte proliferation and differentiation contribute to increases in
adipose tissue mass, yet the mechanisms that underlie these processes ... Cited by 125 - Related articles - BL Direct - All 6 versions
NM Morton, MC Holmes, C Fievet, B Staels, A … - Journal of Biological Chemistry, 2001 - ASBMB Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin
resistance, and impaired glucose tolerance of the metabolic syndrome.
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD-1) catalyzes conversion ... Cited by 213 - Related articles - BL Direct - All 3 versions
- ►endojournals.org E Rask, BR Walker, S Soderberg, DEW … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Cushing's syndrome and the metabolic syndrome share clinical similarities.
Reports of alterations in the hypothalamic-pituitary-adrenal (HPA) axis are
inconsistent, however, in the metabolic syndrome. Recent data highlight the ... Cited by 212 - Related articles - BL Direct - All 6 versions
- ►endojournals.org RC Andrews, O Herlihy, DEW Livingstone, R … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc In summary, in patients with glucose intolerance, cortisol secretion, although
normal, is inappropriately high given enhanced central and peripheral
sensitivity to glucocorticoids. Normal 11ß-HSD 1 activity in adipose ... Cited by 97 - Related articles - BL Direct - All 5 versions
B Davani, A Khan, M Hult, E Mårtensson, S … - Journal of Biological Chemistry, 2000 - ASBMB Metabolic transformation of glucocorticoid hormones constitutes a determinant of
their cell-specific effects. The most important reaction for this class of
steroids is the reversible C11 keto/β-hydroxyl conversion between receptor- ... Cited by 61 - Related articles - All 4 versions
- ►diabetesjournals.org TM Stulnig, U Oppermann, KR Steffensen, GU … - Diabetes, 2002 - Am Diabetes Assoc 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) converts inactive
corticosteroids into biologically active corticosteroids, thereby regulating the
local concentration of active glucocorticoids, such as cortisol. 11β-HSD-1 ... Cited by 87 - Related articles - BL Direct - All 5 versions
