MC Desco, M Asensi, R Márquez, J Martínez-Valls, M … - Diabetes, 2002 - Am Diabetes Assoc The aim of this work was to study the mechanism of free radical formation in type 1 diabetes and
its possible prevention. We have found oxidation of blood glutathione and an increase in plasma
lipoperoxide levels in both human type 1 diabetes and experimental diabetes. Peroxide ... Cited by 118 - Related articles - BL Direct - All 4 versions
P by Allopurinol - DIABETES, 2002 - Am Diabetes Assoc The aim of this work was to study the mechanism of free radical formation in type 1 diabetes and
its possible prevention. We have found oxidation of blood glutathi- one and an increase in plasma
lipoperoxide levels in both human type 1 diabetes and experimental diabetes. Peroxide ... Related articles - All 3 versions
S Matsumoto, I Koshiishi, T Inoguchi, H … - Free Radical …, 2003 - informahealthcare.com Reactive oxygen species (ROS) may play key roles in vascular inflammation and atherogenesis
in patients with diabetes. In this study, xanthine oxidase (XO) system was examined as a potential
source of superoxide in mice with streptozotocin (STZ)-induced experimental diabetes. ... Cited by 36 - Related articles - BL Direct - All 6 versions
YK Kim, MS Lee, SM Son, IJ Kim, WS Lee, BY Rhim, … - Diabetes, 2002 - Am Diabetes Assoc Superoxide anion can modulate vascular smooth muscle tone and is potentially involved in diabetic
vascular complications. The present study was undertaken to characterize both vascular production
and the enzymatic source of superoxide anion in type 2 diabetic rats. In the thoracic aorta ... Cited by 102 - Related articles - BL Direct - All 5 versions
T Inoguchi, P Li, F Umeda, HY Yu, M … - DIABETES-NEW …, 2000 - Am Diabetes Assoc Recent studies have revealed that vascular cells can produce reactive oxygen species
(ROS) through NAD(P)H oxidase, which may be involved in vascular injury. However, the pathological
role of vascular NAD(P)H oxidase in diabetes or in the insulin-resistant state remains ... Cited by 591 - Related articles - BL Direct - All 6 versions
P Martín-Gallán, A Carrascosa, M Gussinye, … - Free radical …, 2005 - informahealthcare.com Abstract Increased oxidative stress has emerged as a potential mechanism implicated in the
pathogenesis, progression and cell dysfunction associated with many diseases including
diabetes. In routine clinical practice, the estimation of the degree of oxidative damage and ... Cited by 21 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org R Butler, AD Morris, JJF Belch, A Hill, AD Struthers - Hypertension, 2000 - Am Heart Assoc Abstract—Therapeutic strategies against free radicals have mostly focused on the augmentation
of antioxidant defenses (eg, vitamins C and E). A novel approach is to prevent free radical generation
by the enzyme system xanthine oxidase. We examined whether the inhibition of xanthine ... Cited by 219 - Related articles - BL Direct - All 7 versions
G Baydas, RJ Reiter, A Yasar, M Tuzcu, I Akdemir, … - Free Radical Biology and …, 2003 - Elsevier Hyperglycemia plays a critical role in the development and progression of diabetic
neuropathy. One of the mechanisms by which hyperglycemia causes neural degeneration is
via the increased oxidative stress that accompanies diabetes. Metabolic and oxidative ... Cited by 40 - Related articles - All 5 versions
- ►ahajournals.org CAJ Farquharson, R Butler, A Hill, JJF Belch, AD … - Circulation, 2002 - Am Heart Assoc Methods and Results— We performed a randomized, placebo-controlled, double-blind crossover
study on 11 patients with New York Heart Association class II-III chronic heart failure, comparing
300 mg allopurinol daily (1 month) versus placebo. Endothelial function was assessed by ... Cited by 221 - Related articles - BL Direct - All 7 versions
T Sano, F Umeda, T Hashimoto, H Nawata, H Utsumi - Diabetologia, 1998 - Springer The generation of reactive oxygen species and free radicals has been shown to be increased
in patients with diabetes mellitus [1, 2]. Free radicals generated through glycation may accelerate
oxidation reactions in the vascular walls, thereby contributing significant- Cited by 104 - Related articles - BL Direct - All 4 versions
