S Mohr, X Xi, J Tang, TS Kern - Diabetes, 2002 - Am Diabetes Assoc Apoptosis of retinal capillary cells begins early in diabetes and likely
contributes to the capillary obliteration that is an important feature of
diabetic retinopathy. Caspases are proteolytic enzymes that are closely ... Cited by 82 - Related articles - BL Direct - All 4 versions
- ►iovs.org PM Martin, P Roon, TK Van Ells, V Ganapathy … - Investigative ophthalmology & visual science, 2004 - ARVO RESULTS. Morphometric analysis of retinal cross sections of mice that had been
diabetic 14 weeks showed 20% to 25% fewer cells in the ganglion cell layer
compared with age-matched control mice. There was a modest, but ... Cited by 84 - Related articles - BL Direct - All 3 versions
RA Kowluru, P Koppolu - Free Radical Research, 2002 - informahealthcare.com Apoptosis of retinal endothelial cells and pericytes is postulated to contribute
to the development of retinopathy in diabetes. The goal of this study is to
investigate diabetes- induced activation of retinal caspase-3, an apoptosis ... Cited by 60 - Related articles - BL Direct - All 7 versions
- ►iovs.org LL Kusner, VP Sarthy, S Mohr - Investigative ophthalmology & visual science, 2004 - ARVO PURPOSE. A recent study demonstrated that retinal Müller cells undergo
hyperglycemia-induced apoptosis in vitro. Translocation of
glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the cytosol to the ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►iovs.org TS Kern, J Tang, M Mizutani, RA Kowluru, RH … - Investigative ophthalmology & visual science, 2000 - ARVO METHODS. Rats with alloxan-induced diabetes and rats fed a 30% galactose diet
(known to induce diabetic-like retinopathy) were assigned randomly to receive
diet with (2.5 g/kg diet) or without AMG. After 6 to 8 months of diabetes ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] HP Hammes, HJ Federoff, M Brownlee - Molecular Medicine, 1995 - pubmedcentral.nih.gov Background: Chronic diabetes causes structural changes in theretinal capillaries
of nearly all patients with a disease duration of more than 15 years. Acellular
occluded vessels cause hypoxia, which stimulates sight- threatening ... Cited by 81 - Related articles - All 4 versions
V Asnaghi, C Gerhardinger, T Hoehn, A … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and
increased expression of glial fibrillary acidic protein (GFAP) observed in the
rat after a short duration of diabetes are mediated by polyol pathway ... Cited by 105 - Related articles - BL Direct - All 4 versions
JA Vincent, S Mohr - Diabetes, 2007 - Am Diabetes Assoc The proinflammatory cytokine, interleukin (IL)-1β, is known to induce vascular
dysfunction and cell death. We investigated the role of IL-1β and caspase-1
(the enzyme that produces it) in diabetes-induced degeneration of retinal ... Cited by 19 - Related articles - BL Direct - All 5 versions
JK Krady, A Basu, CM Allen, Y Xu, KF … - Diabetes, 2005 - Am Diabetes Assoc Diabetes leads to vascular leakage, glial dysfunction, and neuronal apoptosis
within the retina. The goal of the studies reported here was to determine the
role that retinal microglial cells play in diabetic retinopathy and assess ... Cited by 81 - Related articles - All 10 versions
- ►iovs.org Q Li, DG Puro - Investigative ophthalmology & visual science, 2002 - ARVO PURPOSE. A decrease in the ability of Müller cells to remove glutamate from the
extracellular space may play a critical role in the disruption of glutamate
homeostasis that occurs in the diabetic retina. Because this amino acid is ... Cited by 79 - Related articles - BL Direct - All 3 versions
