LH Canani, DPK Ng, A Smiles, JJ Rogus, JH … - Diabetes, 2002 - Am Diabetes Assoc A polymorphism in the ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene
(ENPP1) (previously known as PC-1), resulting in an amino acid change from
lysine to glutamine at codon 121 (K121Q), is associated with insulin ... Cited by 42 - Related articles - BL Direct - All 4 versions
S De Cosmo, A Argiolas, G Miscio, S Thomas, GP … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc Insulin resistance characterizes type 1 diabetes in patients with albuminuria. A
PC-1 glycoprotein amino acid variant, K121Q, is associated with insulin resis-
tance. We examined the impact of the PC-1 K121Q vari- ant on the rate of ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org P Jacobsen, N Grarup, L Tarnow, HH Parving … - Nephrology Dialysis Transplantation, 2002 - ERA-EDTA Results. Patients carrying the Q allele had a mean rate of decline in GFR during
follow-up of 3.6 ml/min per year (SE 0.4) compared with 4.0 ml/min per year (SE
0.3) in patients with the KK genotype. Other risk factors for progression ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org S De Cosmo, R Trevisan, M Dalla Vestra, M … - Diabetes care, 2003 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A total of 125 patients with type 2 diabetes and
abnormal albumin excretion rate (AER) (range 20–5,416 μg/min) were followed
up for 4 years with repeated measurements of glomerular filtration rate ... Cited by 13 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] SK Rasmussen, SA Urhammer, A Pizzuti, SM … - Diabetes, 2000 - Am Diabetes Assoc The human plasma-cell membrane differentiation anti- gen-1 (PC-1) has been shown
to inhibit insulin receptor tyrosine kinase activity. Recently, a K121Q polymor-
phism in the human PC-1 gene was found in a Sicilian population and was ... Cited by 67 - Related articles - BL Direct - All 4 versions
G Endler, C Mannhalter, H Sunder-Plassmann, … - Journal of molecular medicine, 2002 - Springer Abstract Elevated plasma cell membrane glycoprotein 1 (PC-1) expression and the
frequent PC-1 K121Q poly- morphism have recently been associated with insulin
re- sistance. Since insulin resistance represents an important risk factor ... Cited by 28 - Related articles - BL Direct - All 4 versions
BV Costanzo, V Trischitta, R Di Paola, D … - Diabetes, 2001 - Am Diabetes Assoc When overexpressed, the membrane glycoprotein PC-1 may play a role in human
insulin resistance through the inhibition of insulin receptor (IR)
autophosphorylation. A PC-1 variant (K 121 Q, with lysine 121 replaced by ... Cited by 76 - Related articles - BL Direct - All 5 versions
L Frittitta, T Ercolino, M Bozzali, A Argiolas, … - Diabetes, 2001 - Am Diabetes Assoc Glycoprotein PC-1 inhibits insulin signaling and, when overexpressed, plays a
role in human insulin resistance. Mechanisms of PC-1 overexpression are unknown.
We have identified a haplotype in the 3′-untranslated region of the PC-1 ... Cited by 46 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org SD Cosmo, G Miscio, L Zucaro, M Margaglione, A … - Nephrology Dialysis Transplantation, 2002 - ERA-EDTA Background. The DD genotype of the ACE gene predisposes to faster diabetic
nephropathy (DN) progression but its role in DN development is more
controversial. We reported previously, in type 1 diabetic patients, an ... Cited by 20 - Related articles - BL Direct - All 4 versions
HF Gu, P Almgren, E Lindholm, L Frittttta, A … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc We studied whether there is an association between the single nucleotide
polymorphism c.533A>C (K121Q) in the glycoprotein PC-1 gene and features of the
metabolic syn- drome in case-control and intrafamily association studies in ... Cited by 93 - Related articles - BL Direct - All 4 versions
