HBT Christesen, BB Jacobsen, S Odili, C … - Diabetes, 2002 - Am Diabetes Assoc In this study, a second case of hyperinsulinemic hypoglycemia due to activation
of glucokinase is reported. The 14-year-old proband had a history of neonatal
hypoglycemia, treated with diazoxide. He was admitted with coma and ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org AL Gloyn, K Noordam, MAAP Willemsen, S … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GCK) is a key regulatory enzyme in the pancreatic β-cell and
catalyzes the rate-limiting step for β-cell glucose metabolism. We report two
novel GCK mutations (T65I and W99R) that have arisen de novo in two ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org AL Cuesta-Muñoz, H Huopio, T Otonkoski, JM … - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is a glycolytic key enzyme that functions as a glucose sensor
in the pancreatic β-cell, where it governs glucose-stimulated insulin secretion
(GSIS). Heterozygous inactivating mutations in the glucokinase gene (GCK) ... Cited by 69 - Related articles - BL Direct - All 5 versions
B Glaser, P Kesavan, M Heyman, E Davis, A … - The New England journal of medicine, 1998 - nejm.highwire.org Preliminary clinical and genetic data on the study family have been reported
previously. 12 The proband (Subject II-3 in Figure 1A, Figure 1B, Figure 1C, and
Figure 1D), a 31-year-old white man, was seen after losing consciousness ... Cited by 325 - Related articles - BL Direct - All 6 versions
E Alvarez, I Roncero, JA Chowen, P Vázquez … - Journal of Neurochemistry, 2002 - interscience.wiley.com Our previous description of functional glucokinase isoforms in the rat brain has
opened new questions concerning the presence of glucokinase regulatory protein
in the brain and the functional role of its interactions with glucokinase. ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►sciencesignaling.org [PDF] J Grimsby, R Sarabu, WL Corbett, NE Haynes, … - Science, 2003 - sciencemag.org Page 1. DOI: 10.1126/science.1084073 , 370 (2003); 301 Science et al. Joseph Grimsby,
in Diabetes Therapy Allosteric Activators of Glucokinase: Potential Role ... Cited by 187 - Related articles - All 12 versions
- ►diabetesjournals.org M Shiota, C Postic, Y Fujimoto, TL Jetton, K … - Diabetes, 2001 - Am Diabetes Assoc Transgenic mice that overexpress the entire glucokinase (GK) gene locus have
been previously shown to be mildly hypoglycemic and to have improved tolerance
to glucose. To determine whether increased GK might also prevent or ... Cited by 59 - Related articles - BL Direct - All 7 versions
- ►cell.com K Kamata, M Mitsuya, T Nishimura, J Eiki, Y … - Structure, 2004 - Elsevier Glucokinase is a monomeric enzyme that displays a low affinity for glucose and a
sigmoidal saturation curve for its substrate, two properties that are important
for its playing the role of a glucose sensor in pancreas and liver. The ... Cited by 127 - Related articles - All 10 versions
UJ Desai, ED Slosberg, BR Boettcher, SL … - Diabetes, 2001 - Am Diabetes Assoc Hyperglycemia of diabetes is caused in part by perturbation of hepatic glucose
metabolism. Hepatic glucokinase (GK) is an important regulator of glucose
storage and disposal in the liver. GK levels are lowered in patients with ... Cited by 63 - Related articles - BL Direct - All 5 versions
D Zelent, H Najafi, S Odili, C Buettger, H Weik … - Biochemical Society Transactions, 2005 - bst.portlandpress.com The enzyme GK (glucokinase), which phosphorylates glucose to form glucose
6-phosphate, serves as the glucose sensor of insulin-producing b-cells. GK has
thermodynamic, kinetic, regulatory and molecular genetic characteristics ... Cited by 42 - Related articles - Cached - All 9 versions
