- ►diabetesjournals.org DM Muoio, JM Way, CJ Tanner, DA Winegar, SA … - Diabetes, 2002 - Am Diabetes Assoc In humans, skeletal muscle is a major site of peroxisome proliferator–activated receptor-α
(PPAR-α) expression, but its function in this tissue is unclear. We investigated the role of
hPPAR-α in regulating muscle lipid utilization by studying the effects of a highly selective ... Cited by 89 - Related articles - BL Direct - All 6 versions
- ►physiology.org A Minnich, N Tian, L Byan, G Bilder - American Journal of …, 2001 - Am Physiological Soc The proposed mechanism for the triglyceride (TG) lowering by fibrate drugs is via activation of
the peroxisome proliferator-activated receptor- (PPAR ). Here we show that a PPAR agonist,
ureido-fibrate-5 (UF-5), ~200-fold more potent than fenofibric acid, exerts TG-lowering ... Cited by 87 - Related articles - BL Direct - All 3 versions
DM Muoio, PS MacLean, DB Lang, S Li, JA … - Journal of Biological …, 2002 - ASBMB Ablation of peroxisome proliferator activated receptor (PPAR) α, a lipid-activated transcription
factor that regulates expression of β-oxidative genes, results in profound metabolic abnormalities
in liver and heart. In the present study we used PPARα knockout (KO) mice to determine ... Cited by 233 - Related articles - BL Direct - All 6 versions
- ►physiology.org ME Young, GW Goodwin, J Ying, P … - American Journal of …, 2001 - Am Physiological Soc Malonyl-CoA decarboxylase (MCD) catalyzes the degradation of malonyl-CoA, an important
modulator of fatty acid oxidation. We hypothesized that increased fatty acid availability would
increase the expression and activity of heart and skeletal muscle MCD, thereby promoting ... Cited by 64 - Related articles - BL Direct - All 2 versions
DM Muoio, PS MacLean, DB Lang, S Li, JA Houmard, … - J Biol Chem, 2002 - ASBMB Deborah M. Muoio 1* , Paul S. MacLean 2 , David B. Lang 2 , Shi Li 1 , Joseph A. Houmard 2
, James M. Way 3 , ... Deborah A. Winegar 3 , J. Christopher Corton 4 , G. Lynis Dohm 2 and
William E. Kraus 1 ... 1 Departments of Medicine and Cell Biology, Duke University ... Cited by 2 - Related articles - All 2 versions
JM Ye, PJ Doyle, MA Iglesias, DG Watson, GJ Cooney, … - Diabetes, 2001 - Am Diabetes Assoc Peroxisome proliferator—activated receptor (PPAR)-α agonists lower circulating lipids, but the
consequences for muscle lipid metabolism and insulin sensitivity are not clear. We investigated
whether PPAR-α activation improves insulin sensitivity in insulin-resistant rats and ... Cited by 240 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] MC Sugden, A Kraus, RA Harris, MJ … - Biochemical Journal, 2000 - pubmedcentral.nih.gov Using immunoblot analysis with antibodies raised against recombinant pyruvate dehydrogenase
kinase (PDK) isoenzymes PDK2 and PDK4, we demonstrate selective changes in PDK isoenzyme
expression in slow-twitch versus fast-twitch skeletal muscle types in response to ... Cited by 58 - Related articles - All 6 versions
JUILAN SU, CJ SIMMONS, B WISELY, B ELLIS, DA … - Hybridoma, 1998 - liebertonline.com Page 1. HYBRIDOMA Volume 17, Number 1, 1998 Mary Ann Liebert, Inc. Monitoring of PPAR
Alpha Protein Expression in Human Tissue by the Use of PPAR Alpha-Specific MAbs JUI-LAN
SU,1 CAROLINE J. SIMMONS,2 BRUCE WISELY,3 BYRON ELLIS,1 and ... Cited by 43 - Related articles - BL Direct - All 3 versions
- ►physiology.org JY Kim, RC Hickner, RL Cortright, GL … - American Journal of …, 2000 - Am Physiological Soc The purpose of this study was to discern cellular mechanisms that contribute to the suppression
of lipid oxidation in the skeletal muscle of obese individuals. Muscle was obtained from obese
[body mass index (BMI), 38.3 ± 3.1 kg/m 2 ] and lean (BMI, 23.8 ± 0.9 kg/m 2 ) women, ... Cited by 182 - Related articles - BL Direct - All 5 versions
J An, DM Muoio, M Shiota, Y Fujimoto, GW Cline, GI … - Nature medicine, 2004 - nature.com Lipid infusion or ingestion of a high-fat diet results in insulin resistance, but the mechanism underlying
this phenomenon remains unclear. Here we show that, in rats fed a high-fat diet,
whole-animal, muscle and liver insulin resistance is ameliorated following hepatic ... Cited by 119 - Related articles - BL Direct - All 5 versions
