PW Hruz, H Murata, H Qiu, M Mueckler - Diabetes, 2002 - Am Diabetes Assoc The use of HIV protease inhibitors (PIs) has been associated with several
metabolic changes, including lipodystrophy, hyperlipidemia, and insulin
resistance. The etiology of these adverse effects remains unknown. PIs have ... Cited by 76 - Related articles - BL Direct - All 4 versions
H Murata, PW Hruz, M Mueckler - Aids, 2002 - journals.lww.com Objectives: To determine the relative sensitivities of glucose transporter
isoforms to the protease inhibitor indinavir and to determine the kinetic
mechanism of indinavir- mediated Glut4 isoform inhibition. Methods: The ... Cited by 157 - Related articles - All 3 versions
M Schütt, M Meier, M Meyer, J Klein, SP Aries … - Diabetologia, 2000 - Springer Patients treated with human immunodeficiency vi- rus-1 (HIV-1) protease
inhibitors frequently develop IGT or diabetes [1]. The underlying cause seems to
be a protease inhibitor-induced insulin resistance [1]. We investigated ... Cited by 43 - Related articles - BL Direct - All 3 versions
HJ Woerle, PR Mariuz, C Meyer, RC Reichman … - Diabetes, 2003 - Am Diabetes Assoc The mechanisms responsible for the deterioration in glucose tolerance associated
with protease inhibitor–containing regimens in HIV infection are unclear.
Insulin resistance has been implicated as a major factor, but the affected ... Cited by 99 - Related articles - BL Direct - All 9 versions
- ►uva.nl [PDF] M van der Valk, PH Bisschop, JA Romijn, MT … - Aids, 2001 - journals.lww.com From the a National AIDS Therapy Evaluation Center (NATEC) and Department of
Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center,
Amsterdam, the b Department of Endocrinology and Metabolism, Academic ... Cited by 103 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org A Rudich, S Vanounou, K Riesenberg, M Porat … - Diabetes, 2001 - Am Diabetes Assoc HIV protease inhibitors (HPIs) are potent antiretroviral agents clinically used
in the management of HIV infection. Recently, HPI therapy has been linked to the
development of a metabolic syndrome in which adipocyte insulin resistance ... Cited by 106 - Related articles - BL Direct - All 3 versions
MA Noor, T Seneviratne, FT Aweeka, JC Lo, … - Aids, 2002 - journals.lww.com From the From the Department of a Medicine, University of California, the b
Metabolism and Endocrine Sections, San Francisco Department of Veterans Affairs
Medical Center, the Department of c Pharmacology University of California, ... Cited by 224 - Related articles - BL Direct - All 8 versions
J Hertel, H Struthers, CB Horj, PW Hruz - Journal of Biological Chemistry, 2004 - ASBMB Human immunodeficiency virus (HIV) protease inhibitors (PIs) act as reversible
noncompetitive inhibitors of GLUT4 with binding affinities in the low micromolar
range and are known to contribute to alterations in glucose homeostasis ... Cited by 42 - Related articles - All 5 versions
- ►diabetesjournals.org LA Nolte, KE Yarasheski, K Kawanaka, J … - Diabetes, 2001 - Am Diabetes Assoc In many patients with human immunodeficiency virus (HIV) treated with HIV
protease inhibitors, a complication develops that resembles abdominal obesity
syndrome, with insulin resistance and glucose intolerance that, in some ... Cited by 74 - Related articles - BL Direct - All 5 versions
H Murata, PW Hruz, M Mueckler - Journal of Biological Chemistry, 2000 - ASBMB Retroviral protease inhibitors used as therapy for HIV-1 infection have been
causally associated with serious metabolic side effects, including peripheral
lipodystrophy, hyperlipidemia, insulin resistance, and in some cases, overt ... Cited by 374 - Related articles - BL Direct - All 7 versions
