JA Pospisilik, SG Stafford, HU Demuth, R Brownsey, W … - Diabetes, 2002 - Am Diabetes Assoc The incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide
1 (GLP-1) are responsible for >50% of nutrient-stimulated insulin secretion. After being released
into the circulation, GIP and GLP-1 are rapidly inactivated by the circulating enzyme ... Cited by 135 - Related articles - BL Direct - All 6 versions
B Sudre, P Broqua, RB White, D Ashworth, DM Evans, … - Diabetes, 2002 - Am Diabetes Assoc Acute suppression of dipeptidyl peptidase IV (DPP-IV) activity improves glucose tolerance in
the Zucker fatty rat, a rodent model of impaired glucose tolerance, through stabilization of
glucagon-like peptide (GLP)-1. This study describes the effects of a new and potent ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, … - Diabetes, 2002 - Am Diabetes Assoc Upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are rapidly cleaved and inactivated by
the enzyme dipeptidyl peptidase IV (DP IV). Long-term administration of specific DP IV ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►pasteur.ac.ir [PDF] B Ahrén, JJ Holst, H Mårtensson, B Balkan - European journal of pharmacology, 2000 - Elsevier We explored whether inhibition of the enzyme dipeptidyl peptidase IV (DPP IV) increases endogenous
levels of glucagon-like peptide-1 (GLP-1) and improves glucose tolerance and insulin secretion
in mice. Glucose (150 mg) was administered through a gastric gavage with or without the ... Cited by 133 - Related articles - All 5 versions
B Balkan, L Kwasnik, R Miserendino, JJ Holst, X Li - Diabetologia, 1999 - Springer Control of prandial plasma concentrations of sub- strates, particularly glucose, is aided by
incretins. In- cretins are hormones released by the digestive tract in response to ingested nutrients
[1]. The role of in- cretins is to sensitize beta cells to stimulation by glu- Cited by 158 - Related articles - BL Direct - All 3 versions
- ►eje-online.org [PDF] MK Reimer, JJ Holst, B Ahren - European Journal of Endocrinology, 2002 - EFES Objectives: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase
IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence
of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J ... Cited by 107 - Related articles - BL Direct - All 9 versions
BO Ahrén, E Simonsson, H Larsson, M Landin- … - Diabetes Care, 2002 - Am Diabetes Assoc OBJECTIVE—Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality
for type 2 diabetes. To circumvent the drawback of the short half-life of GLP-1, inhibitors of the
GLP-1–degrading enzyme dipeptidyl peptidase IV (DPP IV) have been examined. Such ... Cited by 276 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org JA Pospisilik, J Martin, T Doty, JA Ehses, N Pamir, FC … - Diabetes, 2003 - Am Diabetes Assoc Recent studies into the physiology of the incretins glucose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide-1 (GLP-1) have added stimulation of β-cell growth,
differentiation, and cell survival to well-documented, potent insulinotropic effects. ... Cited by 163 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] RA Pederson, HA White, D Schlenzig, RP Pauly, CH … - Diabetes, 1998 - Am Diabetes Assoc The hormones glucose-dependent insulinotropic polypep- tide (GIP) and glucagon-like peptide
(GLP)-1 act on the pancreas to potentiate glucose-induced insulin secretion (enteroinsular
axis). These hormones (incretins) are rapidly hydrolyzed by the circulating enzyme ... Cited by 202 - Related articles - BL Direct - All 5 versions
- ►endocrinology-journals.org [PDF] CF Deacon, S Wamberg, P Bie, TE Hughes, … - Journal of …, 2002 - Soc Endocrinology The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are degraded by dipeptidyl peptidase IV (DPP IV), thereby losing insulinotropic
activity. DPP IV inhibition reduces exogenous GLP-1 degradation, but the extent of ... Cited by 63 - Related articles - BL Direct - All 3 versions
