S Banarer, VP McGregor, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc Because absence of the glucagon response to falling plasma glucose
concentrations plays a key role in the pathogenesis of iatrogenic hypoglycemia
in patients with insulin-deficient diabetes and the mechanism of this ... Cited by 67 - Related articles - BL Direct - All 7 versions
KM Hope, POT Tran, H Zhou, E Oseid, E … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell
function during hypoglycemia has not been assessed previously in isolated
islets, largely because they characteristically do not respond to glucose ... Cited by 43 - Related articles - BL Direct - All 4 versions
H Zhou, POT Tran, S Yang, T Zhang, E LeRoy … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is
lost in insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes
that a sudden cessation of insulin secretion from ß-cells into the portal ... Cited by 39 - Related articles - BL Direct - All 4 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory
response to hypoglycemia states that a decrease in arterial glucose → a
decrease in β-cell insulin secretion → a decrease in tonic α-cell ... Cited by 60 - Related articles - All 6 versions
Z Israelian, NR Gosmanov, E Szoke, M Schorr, … - Diabetes Care, 2005 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Twelve subjects with type 2 diabetes who have been
insulin requiring were studied as a model of advanced β-cell failure. Glucagon
responses were examined during a 90-min hypoglycemic clamp (∼2.8 mmol/l) ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SR Peacey, A Rostami-Hodjegan, E George, … - Journal of Clinical Endocrinology & Metabolism, 1997 - Endocrine Soc Disruption of intraislet mechanisms could account for the impaired glucagon
response to hypoglycemia in type 1 diabetes. However, in contrast to animals,
there is conflicting evidence that such mechanisms operate in humans. We ... Cited by 27 - Related articles - BL Direct - All 5 versions
SA Segel, DS Paramore, PE Cryer - Diabetes, 2002 - Am Diabetes Assoc We tested the hypotheses that the glucagon response to hypoglycemia is reduced
in patients who are approaching the insulin-deficient end of the spectrum of
type 2 diabetes and that recent antecedent hypoglycemia shifts the glycemic ... Cited by 112 - Related articles - BL Direct - All 8 versions
D LlU, E MOBERG, M KOLLIND, PERE LINS … - Journal of Clinical Endocrinology & Metabolism, 1991 - Endocrine Soc In an attempt to clarify whether circulating insulin per se exerts an inhibitory
effect on the hormonal responses to hypoglycemia, with special emphasis on
glucagon secretion, nine healthy volunteers were exposed to low dose (244 ... Cited by 56 - Related articles - All 4 versions
- ►diabetesjournals.org [PDF] GJ Taborsky, B Ahren, PJ Havel - Diabetes, 1998 - Am Diabetes Assoc This article examines the role of the autonomic nervous system in mediating the
increase of glucagon secretion observed during insulin-induced hypoglycemia
(IIH). In the first section, we briefly review the importance of the -cell ... Cited by 103 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] H Maruyama, A Hisatomi, L Orci, GM Grodsky … - Journal of Clinical Investigation, 1984 - pubmedcentral.nih.gov Abstract. To determine if glucagon secretion is under physiological control of
intra-islet insulin, pan- creata from normal rats were perfused at a 100 mg/dl
glucose concentration with either guinea pig antiinsulin serum or normal ... Cited by 120 - Related articles - All 5 versions
