MK Lingohr, LM Dickson, JF McCuaig, SR … - Diabetes, 2002 - Am Diabetes Assoc Transforming growth factor (TGF)-α- and epidermal growth factor (EGF)-induced
signal transduction was directly compared with that of glucose and insulin-like
growth factor-1 (IGF-1) in INS-1 cells. TGF-α/EGF transiently (<20 min) ... Cited by 85 - Related articles - BL Direct - All 7 versions
LM Dickson, MK Lingohr, J McCuaig, SR Hugl … - Journal of Biological Chemistry, 2001 - ASBMB It has been shown that IGF-1-induced pancreatic -cell proliferation is
glucose-dependent; however, the mechanisms responsible for this glucose
dependence are not known. Adenoviral mediated expression of constitutively ... Cited by 84 - Related articles - BL Direct - All 6 versions
MK Lingohr, LM Dickson, CE Wrede, JF … - Molecular and cellular endocrinology, 2003 - Elsevier IRS-2 plays an important role in the control of pancreatic β-cell growth,
however it is unclear if other IRS family members are also involved. Using
recombinant adenoviruses, IRS-1, -2 and -3 expression was varied in the ... Cited by 19 - Related articles - All 5 versions
- ►diabetesjournals.org I Briaud, MK Lingohr, LM Dickson, CE Wrede … - Diabetes, 2003 - Am Diabetes Assoc Glucose can activate the mitogen-activated kinases, Erk-1/2, and the
ribosomal-S6 kinase, p70 S6K , in β-cells, contributing to an increase in
mitogenesis. However, the signaling mechanism by which glucose induces ... Cited by 78 - Related articles - BL Direct - All 4 versions
CJ Rhodes, MF White - European Journal of Clinical Investigation, 2002 - whitelabs.org Abstract Tightly co-ordinated control of both insulin action and secretion is
required in order to maintain glucose homeostasis. Gene knockout experiments
have helped to define key signalling molecules that affect insulin action, ... Cited by 95 - Related articles - View as HTML - BL Direct - All 7 versions
- ►jbc.org SR Hugl, MF White, CJ Rhodes - Journal of Biological Chemistry, 1998 - ASBMB Nutrients and certain growth factors stimulate pancreatic -cell mitogenesis,
however, the appropriate mitogenic signal transduction pathways have not been
defined. In the glucose-sensitive pancreatic -cell line, INS-1, it was ... Cited by 168 - Related articles - BL Direct - All 7 versions
CE Wrede, LM Dickson, MK Lingohr, I Briaud … - Journal of Biological Chemistry, 2002 - ASBMB Free fatty acids (FFA) have been reported to reduce pancreatic -cell mitogenesis
and to increase apoptosis. Here we show that the FFA, oleic acid, increased
apoptosis 16-fold in the pancreatic -cell line, INS-1, over a 18-h period ... Cited by 127 - Related articles - BL Direct - All 6 versions
MK Lingohr, LM Dickson, CE Wrede, I Briaud … - Molecular and cellular endocrinology, 2003 - Elsevier IRS-2 plays a pivotal role in the control of pancreatic β-cell growth. Here,
the effect of altering IRS-2 expression levels in the pancreatic β-cell line,
INS-1, was examined. Adenoviral-mediated increased in IRS-2 protein levels ... Cited by 42 - Related articles - All 5 versions
- ►nih.gov AM Hennige, DJ Burks, U Ozcan, RN Kulkarni, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig The insulin receptor substrate-2 (Irs2) branch of the insulin/IGF signaling
system coordinates peripheral insulin action and pancreatic β cell function, so
mice lacking Irs2 display similarities to humans with type 2 diabetes. Here ... Cited by 132 - Related articles - BL Direct - All 10 versions
I Briaud, LM Dickson, MK Lingohr, JF … - Journal of Biological Chemistry, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to
β-cell survival, but the mechanisms that control this are complex and
undefined. Here in pancreatic β-cells (INS-1), chronic exposure (>8 h) to ... Cited by 44 - Related articles - All 5 versions
