- ►diabetesjournals.org AK Busch, D Cordery, GS Denyer, TJ Biden - Diabetes, 2002 - Am Diabetes Assoc Chronic lipid exposure is implicated in β-cell dysfunction in type 2 diabetes.
We therefore used oligonucleotide arrays to define global alterations in gene
expression in MIN6 cells after 48-h pretreatment with oleate or palmitate. ... Cited by 86 - Related articles - BL Direct - All 7 versions
J Xiao, S Gregersen, M Kruhøffer, SB … - Endocrinology, 2001 - ncbi.nlm.nih.gov Fatty acids affect insulin secretion of pancreatic beta-cells. Investigating
gene expression profiles may help to characterize the underlying mechanism.
INS-1 cells were cultured with palmitate (0, 50, and 200 microM) for up to ... Cited by 41 - Related articles - BL Direct
X Wang, H Li, D De Leo, W Guo, V Koshkin, … - Diabetes, 2004 - Am Diabetes Assoc Gene and Protein Kinase Expression Profiling of ... Reactive Oxygen
Species–Associated Lipotoxicity in the ... Xiaolin Wang, 1 * Hui Li, 1,2 *
Domenica De Leo, 1 Wanbei Guo, 2 Vasilij Koshkin, 1 I. George Fantus, 1,3 Cited by 50 - Related articles - BL Direct - All 4 versions
X Wang, L Zhou, G Li, T Luo, Y Gu, L Qian, X Fu … - Biochemical and Biophysical Research …, 2007 - Elsevier AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. Changes in AMPK activity contribute to the regulation of insulin
secretion. Epidemiological evidence links the ingestion of saturated fatty ... Cited by 13 - Related articles - All 4 versions
K Maedler, J Oberholzer, P Bucher, GA … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
monounsaturated fatty acids at different glucose concentrations on human ... Cited by 149 - Related articles - BL Direct - All 5 versions
V Koshkin, X Wang, PE Scherer, CB Chan, … - Journal of Biological Chemistry, 2003 - ASBMB Excessive free fatty acid (FFA) exposure represents a potentially important
diabetogenic condition that can impair insulin secretion from pancreatic -cells.
Because mitochondrial oxidative phosphorylation is a main link between ... Cited by 64 - Related articles - BL Direct - All 5 versions
M Dubois, J Kerr-Conte, V Gmyr, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Whether excess glucose (glucotoxic- ity) and excess
non-esterified fatty acids (lipotoxicity) act synergistically or separately to
alter beta-cell func- tion on Type 2 diabetes remains controversial. We ex- ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids
were tested in ß(INS-1)-cells cultured in the absence of serum, a condition
known to alter cell survival in various systems. This may in part mimic the ... Cited by 82 - Related articles - BL Direct - All 8 versions
- ►shouxi.net AK Busch, E Gurisik, DV Cordery, M Sudlow, … - Diabetes, 2005 - Am Diabetes Assoc Increased availability of fatty acids causes cell death and dysfunction in
β-cell lines, isolated islets, and animal models of diabetes. From the MIN6
β-cell line, we selected two subpools that are resistant to ... Cited by 40 - Related articles - BL Direct - All 5 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function
observed in type 2 diabetes. Here we examine the effect of saturated and
unsaturated fatty acids at different glucose concentrations on β-cell ... Cited by 221 - Related articles - BL Direct - All 7 versions
