- ►alaskaclinicaltrials.org [PDF] H Reijonen, EJ Novak, S Kochik, A … - Diabetes, 2002 - Am Diabetes Assoc Soluble HLA-DR401 or -DR404 tetramers containing a peptide corresponding to an
immunodominant epitope from human GAD65 were used to analyze peripheral blood
T-cells of newly diagnosed type 1 diabetic patients and at-risk subjects. ... Cited by 104 - Related articles - BL Direct - All 13 versions
- ►jimmunol.org S Reichstetter, RA Ettinger, AW Liu, JA … - The Journal of Immunology, 2000 - Am Assoc Immnol The polyclonal nature of T cells expanding in an ongoing immune response results
in a range of disparate affinities and activation potential. Recently developed
human class II tetramers provide a means to analyze this diversity by ... Cited by 51 - Related articles - BL Direct - All 10 versions
R Mallone, SA Kochik, EM Laughlin, VH … - Diabetes, 2004 - Am Diabetes Assoc The activation requirements of autoreactive CD4 + T-cells were investigated in
GAD65-specific HLA-DR0401–restricted clones derived from a diabetic patient
using major histocompatibility complex (MHC) class II tetramers (TMrs) as ... Cited by 22 - Related articles - BL Direct - All 5 versions
BO Roep, MA Atkinson, PM van Endert, PA … - Journal of Autoimmunity, 1999 - Elsevier Type 1 diabetes is thought to result from a T cell-mediated destruction of the
pancreatic β-cells. Multiple and sometimes conflicting studies have identified
a variety of aberrations in the cellular immune response to autoantigens in ... Cited by 100 - Related articles - BL Direct - All 5 versions
- ►pnas.org GT Nepom, JD Lippolis, FM White, S … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences T cell recognition of autoantigens is critical to progressive immune-mediated
destruction of islet cells, which leads to autoimmune diabetes. We identified a
naturally presented autoantigen from the human islet antigen glutamic acid ... Cited by 63 - Related articles - BL Direct - All 9 versions
- ►nih.gov JD Trudeau, C Kelly-Smith, CB Verchere, JF … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Address correspondence to: Rusung Tan, Department of Pathology and Laboratory
Medicine, British Columbia's Children's Hospital, 4480 Oak Street, Vancouver,
British Columbia V6H 3V4, Canada. Phone: (604) 875-3605; Fax: (604) ... Cited by 112 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org EJ Novak, SA Masewicz, AW Liu, A … - International Immunology, 2001 - Jpn Soc Immunol Antigen-specific T cells acquire a distinctive phenotype during activation, with
characteristic acquisition of surface markers and patterns of gene expression.
Early after antigen stimulation, CD4 + T lymphocytes increase their surface ... Cited by 51 - Related articles - BL Direct - All 9 versions
S Casares, A Hurtado, RC McEvoy, A … - Nature Immunology, 2002 - nature.com Type 1 diabetes is an organ-specific autoimmune disease that is mediated by
autoreactive T cells. We show here that administration of a soluble dimeric
peptide−major histocompatibility complex (pMHC) class II chimera (DEF) to ... Cited by 63 - Related articles - BL Direct - All 3 versions
NC Schloot, G Meierhoff, M Karlsson Faresjö … - Journal of Autoimmunity, 2003 - Elsevier The identification of sensitive assay formats capable of distinguishing islet
autoreactive T cells directly ex vivo in blood is a major goal in type 1
diabetes research. Recently, much interest has been shown in the cytokine ... Cited by 43 - Related articles - All 4 versions
- ►alaskaclinicaltrials.org [PDF] V Öling, J Marttila, J Ilonen, WW Kwok, G … - Journal of Autoimmunity, 2005 - Elsevier In type 1 diabetes the major loss of insulin producing beta-cells is caused by
autoreactive T-cells specific for antigens expressed by the pancreatic islets.
In this study we have analyzed the prevalence of glutamate decarboxylase 65 ... Cited by 23 - Related articles - All 8 versions
